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A systematic literature review of burden of illness in adults with uncontrolled moderate/severe asthma

期刊

RESPIRATORY MEDICINE
卷 191, 期 -, 页码 -

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W B SAUNDERS CO LTD
DOI: 10.1016/j.rmed.2021.106670

关键词

Asthma burden; Asthma control; Clinical burden; Economic burden; Health-related quality of life; Systematic literature review

资金

  1. GSK [HO-18-17246]

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This article provides a systematic review of the burden of moderate/severe uncontrolled asthma, including prevalence, clinical measures, health-related quality of life, and economic burden. It reveals that patients with uncontrolled asthma have poor lung function, substantial exacerbation burden, and impaired quality of life. The direct, indirect, and total costs associated with managing uncontrolled asthma are also significant.
Background: There are limited published data on the burden of moderate/severe uncontrolled asthma. Methods: We conducted a systematic literature review to better understand the impact of moderate-to-severe asthma in the US, the UK, Germany, France, Italy, Spain, Canada, Japan, and Australia in terms of prevalence, clinical measures, health-related quality of life (HRQoL) and economic burden, for patients whose asthma is uncontrolled despite inhaled corticosteroid/long-acting beta(2)-agonist (ICS/LABA) therapy. Results: The prevalence of uncontrolled asthma among patients with moderate/severe disease varied but was as high as 100% in some subgroups. Patients with uncontrolled asthma generally had poor lung function (mean/median pre-bronchodilator forced expiratory volume in 1 second [FEV1]: 1.69-2.45 L; mean/median prebronchodilator percent predicted FEV1: 57.2-79.7). There was also a substantial but variable exacerbation burden associated with uncontrolled asthma, with the annualised rate of exacerbations ranging from 1.30 to 7.30 when considering various patient subgroups. Furthermore, the annualised rate of severe exacerbations ranged from 1.66 to 3.60. The HRQoL burden measured using disease-specific and generic instruments consistently demonstrated substantial impairment of HRQoL for those with uncontrolled asthma; Asthma Quality of Life Questionnaire scores ranged from 3.00 to 5.20, whilst EurQol-5 Dimensions index scores ranged from 0.53 to 0.59. Direct, indirect and total costs together with consumption of other healthcare resources associated with managing uncontrolled asthma were also substantial in the population studied; no caregiver burden was identified. Conclusions: Our findings suggest that significant unmet needs exist for patients with uncontrolled asthma despite the availability of ICS/LABA therapy. Novel treatments are needed to help reduce the burden to patients, healthcare systems and society.

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