Five novel dinuclear copper(II) complexes: Crystal structures, properties, Hirshfeld surface analysis and vitro antitumor activity study

Five dinuclear copper(II) complexes have been synthesized with three kinds of Schiff bases and Cu (NO3)(2)center dot H2O in different solvent systems: [Cu-2(bdhc)(CH3OH)(NO3)(dmf)(2)] (1), [Cu-2(bdhc)(CH3CH2OH) (NO3)(dmf)(2)] (2) [Cu-2(bchc)(CH3CH2OH)(NO3)(dmf)(2)] (3), [Cu-2(bchc)(CH3OH)(NO3)(dmf)(2)] (4), [Cu-2(bbhc)(H2O)(dmf)(2)center dot NO3-H2O (5) (H(3)bdhc is 1,5-bis(3,5-dibromosalicylidene)-carbohydrazide, H3bchc is 1,5-bis(3,5-dichlorosalicylidene)-carbohydrazide, H(3)bbhc is 1,5-bis(5-bromosalicylidene)-carbohydrazide). All the compounds were characterized by IR spectroscopy, Element analysis and X-ray single -crystal diffraction. The anti -proliferative activity of 1-5 was evaluated against a panel of human tumor cells while 3 exhibited a high antitumor activity against T-24, A549, SK-OV-3 and MGC-803. A detailed analysis of Hirshfeld surface and 2D fingerprint plot revealed that 1-5 were supported mainly by H center dot center dot center dot H, C -H center dot center dot center dot X (X = Cl, Br) and O center dot center dot center dot H intermolecular interactions. Fluorescence properties indicate that all the complexes exist fluorescence concentration self -quenching effect. The magnetic properties of 1 from 2 to 300 K are also discussed. (C) 2016 Elsevier B.V. All rights reserved.