期刊
REPRODUCTIVE TOXICOLOGY
卷 107, 期 -, 页码 112-122出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2021.12.004
关键词
Perfluoroalkyl substance; Pregnancy; Polymorphism; Liver X receptor; Birth size; Ponderal index
资金
- Japanese Ministry of Health, Labour, and Welfare, Health and Labour Sciences Research Grants [H29 Kagaku-Ippan-002]
- Scientific Research from the Japan Society for the Promotion of Sciences
- Ministry of Education, Culture, Sports, Science and Technology [15K15220, 18H03035, 18K17348, 19H01071, 19K22730, 20K10445, 2589300403, 26740028]
- Environment Research and Technology Development Fund of the Ministry of the Environment, Government of Japan [5C-1252, 51554]
- Japan Agency for Medical Research and Development (AMED) [21gk0110039h0003]
- Grants-in-Aid for Scientific Research [20K10445, 19H01071, 19K22730, 18K17348, 26740028, 15K15220, 18H03035] Funding Source: KAKEN
This study assessed the associations between PFOS and PFOA levels, maternal genotypes, and birth outcomes. The results showed that interactions between PFOS levels and the maternal genotype of LXRB affected birth size in female infants.
We assessed the associations between perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) levels in third trimester maternal serum, the maternal genotypes of genes encoding nuclear receptors, and birth outcomes. We studied a prospective birth cohort of healthy pregnant Japanese women (n = 372) recruited in Sapporo between July 2002 and October 2005. We analyzed PFOS and PFOA levels using liquid chromatography-tandem mass spectrometry and analyzed 13 single nucleotide polymorphisms (SNPs) of proliferator-activated receptor alpha, gamma, gamma coactivator 1A, delta, constitutive androstane receptor, liver X receptor alpha, and beta (LXRB) using real-time polymerase reaction (PCR). We employed multiple linear regression models to establish the influences of log(10)-transformed PFOS and PFOA levels and maternal genotypes on birth size. In female infants, we identified interactions between PFOS levels, the maternal genotype of LXRB (rs1405655), and birth weight. The estimated mean changes in birth weight in response to PFOS levels, the maternal genotype LXRB (rs1405655)-TC/CC (compared to TT), and their interactions were -502.9 g (95 % confidence interval [CI] = -247.3, -758.5 g), -526.3 g (95 % CI = -200.7, -852.0 g), and 662.1 g (95 % CI = 221.0, 1,103.2 g; p(int) = 0.003), respectively. Interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) also significantly affected birth chest circumference and the Ponderal index (p(int) = 0.037 and 0.005, respectively). Thus, interactions between PFOS levels and the maternal genotype of LXRB (rs1405655) affects birth sizes in female infants. We found that certain SNPs modify the effects of PFOS levels on birth size.
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