期刊
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
卷 149, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.rser.2021.111386
关键词
Yarrowia lipolytica; Microbial oils; Culture factors; Cultivation modes; Genetics; Lipids extraction
资金
- National key research and development plan [2019YFC0408700]
- Beijing Science and Technology Project [Z181100002418016]
- Fundamental and Applicationfundamental Research Funds, Guangdong Province [2019A1515110219]
- International Scientific and Technological Cooperation and Exchange Projects [2016YFE0115600]
- Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants, International Science and Technology Cooperation Base for Environmental and Energy Technology of MOST
Yarrowia lipolytica is a promising oleaginous yeast that can synthesize considerable lipids from various, especially low-cost carbon sources, attracting researchers' attention. Research focuses on improving culture conditions, optimizing nutrient elements, adjusting cultivation modes, and utilizing genetic engineering to enhance lipid synthesis. Promising prospects are introduced as references for further study.
Microbial oils have become a research hotspot in alleviating energy challenges and environmental problems because of their potential to be green alternatives of traditional fossil fuels. Yarrowia lipolytica is a promising oleaginous yeast that can utilize various, especially low-cost carbon sources to synthesize considerable lipids more than 30% of dry cell weight, which is attracting researchers' attention. Based on well understanding of its lipid synthesis and metabolism mechanism, various optimization approaches have been studied dispersedly to improve the lipid synthesis and realize the industrial-scale application of Y. lipolytica. Some approaches are focused on improving and optimizing culture conditions, such as temperature, pH value, and rotating speed, etc. Other approaches are dedicated to the optimization of nutrient elements, such as carbon source, nitrogen source type and/or concentration, and C/N ratio, etc. Some adjust the cultivation mode to facilitate nutrient assimi-lation and transformation, and others use genetic engineering to modify this yeast. This review focuses on the comprehensive and detailed analyses of feasible enhancement approaches for lipid synthesis. Some prospects will also be introduced as references for further study.
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