期刊
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
卷 151, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.rser.2021.111597
关键词
Cellulases; Cellulosome; Lignocellulosic biomass; Protein engineering; Thermozymes
资金
- Ministry of Science and Technology, Pakistan [27 (54) /2007-DSA]
Human culture has been exploring the potential of using hyperthermophiles and their enzymes as a bio-competitive alternative to fossil-based fuel resources; research has characterized cellulolytic glycoside hydrolases and discussed engineering techniques to enhance the production and stability of thermostable cellulolytic enzymes.
From an anthropocentric point of view, human culture has been intricately involved in harnessing the potential of lignocellulosic feedstock to bring the bio-competitive alternative of fossil-based fuel resources. In today's scenario, the impact of hyperthermophiles and their enzymes has been intensely investigated for implementation in various high-temperature biotechnological processes. Already characterized archaeal and eubacterial cellulolytic glycoside hydrolase have shown highly impressive catalytic structures and mechanisms. Several sequence and structural factors have simultaneously been proposed to contribute towards the augmented stability of thermophilic proteins. However, state-of-the-art technologies like the rational designing approach and mechanism of directed evolution have emerged as critical toolkits for broadened industrial applications of recombinant proteins. This manuscript discusses the cellulase engineering techniques to enhance the biological production and stability of thermostable cellulolytic enzymes.
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