期刊
REGULATORY TOXICOLOGY AND PHARMACOLOGY
卷 128, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yrtph.2021.105092
关键词
Toxicokinetics; Regulatory toxicology; Risk assessment
资金
- Corteva Agriscience
The database of practical examples in toxicokinetics is growing, highlighting the importance of including TK measurements in animal studies and the future use of non-animal methods in human health risk assessments.
The database of practical examples where toxicokinetic (TK) data has benefitted all stages of the human health risk assessment process are increasingly being published and accepted. This review aimed to highlight and summarise notable examples and to describe the state of the art in this field. The overall recommendation is that for any in vivo animal study conducted, measurements of TK should be very carefully considered for inclusion as the numerous benefits this brings continues to grow, particularly during the current march towards animal free toxicology testing and ambitions to eventually conduct human health risk assessments entirely based upon non-animal methods.
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