期刊
REACTIVE & FUNCTIONAL POLYMERS
卷 170, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.reactfunctpolym.2021.105143
关键词
Borosiloxane composite; Al2O3; Nanoparticles; Antimicrobial activity; Material development
资金
- Ministry of Science and Higher Education of the Russian Federation for large scientific projects in priority areas of scientific and technological development [075-15-2020-775]
- Center for Collective Use of the GPI RAS
A technology for producing a nanocomposite based on borsiloxane polymer and aluminum oxide nanoparticles has been developed, which exhibits antimicrobial properties, low toxicity, and the ability to produce reactive oxygen species. The rate of ROS generation increases with an increase in concentration of Al2O3 NPs, and the nanocomposite affects bacterial cell adhesion.
A technology for producing a nanocomposite based on the borsiloxane polymer and aluminum oxide nano particles (Al2O3 NPs) has been developed. Nanocomposites containing 0.001, 0.01, and 0.1 wt% Al2O3 NPs have been created. It has been shown that the nanocomposite with any content of Al2O3 NPs did not lose the main rheological properties of borsiloxane. The resulting nanomaterial is capable of generating reactive oxygen species (ROS) such as hydrogen peroxide and hydroxyl radicals. The rate of ROS generation increases up to 3 times with an increase in the concentration of Al2O3 NPs. It has been shown that the nanocomposite leads to the formation of long-lived reactive protein species, and is also the reason for the appearance of such a key biomarker of oxidative stress as 8-oxoguanine in DNA. The intensity of the process increases with an increase in the concentration of Al2O3 NPs. Moreover, it was found that bacterial cells adhere to the surfaces of the nanocomposite (reduces the number of bacteria on the substrate by 39 times), and the nanocomposite can detach bacterial cells not only from the surfaces, but also from wetted substrates. The ability to capture bacterial cells is primarily associated with the properties of the polymer; they are weakly affected Al2O3 NPs. The nanocomposite is nontoxic to eukaryotic cells, the surface of the nanocomposite is suitable for eukaryotic cells for colonization. Due to unique physical properties, low cytotoxicity and antimicrobial action, this nanocomposite can be used in medicine and prosthetics.
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