Radiomics for MRI Prediction of Tumor Response after Chemoradiotherapy in Rectal Cancer

Article Radiology, Nuclear Medicine & Medical Imaging

MRI Radiomics Model Predicts Pathologic Complete Response of Rectal Cancer Following Chemoradiotherapy

Jaeseung Shin et al.

Summary: This study evaluated radiomics models based on T2-weighted imaging and diffusion-weighted MRI for predicting pCR after nCRT in LARC and compared their performance with visual assessment by radiologists. The results showed that the MRI-based radiomics model had better classification performance than experienced radiologists for diagnosing pathologic complete response in patients with locally advanced rectal cancer after neoadjuvant chemoradiotherapy.

RADIOLOGY (2022)

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Review Radiology, Nuclear Medicine & Medical Imaging

Re-staging and follow-up of rectal cancer patients with MR imaging when Watch-and-Wait is an option: a practical guide

Ines Santiago et al.

Summary: Organ-sparing therapy has become increasingly relevant in the management of locally-advanced rectal cancer patients who show no apparent viable tumor after neoadjuvant therapy. Assessment for inclusion in a Watch-and-Wait program relies on endoscopic evaluation and MR imaging, with a chance of local regrowth being approximately 25-30%, mostly surgically salvageable if detected early. Strict surveillance is necessary for early detection and management.

INSIGHTS INTO IMAGING (2021)

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Article Oncology

A meta-analysis of the watch-and-wait strategy versus total mesorectal excision for rectal cancer exhibiting complete clinical response after neoadjuvant chemoradiotherapy

Guilin Yu et al.

Summary: Although the local recurrence rate of the W&W group was higher than that of the TME group, other outcomes were similar in the two groups. With the assistance of physical examination and salvage therapy, the W&W strategy could achieve treatment effects similar to the TME approach.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2021)

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Review Radiology, Nuclear Medicine & Medical Imaging

Why did European Radiology reject my radiomic biomarker paper? How to correctly evaluate imaging biomarkers in a clinical setting

Steve Halligan et al.

Summary: This review provides simple explanations on the correct research methods for developing and evaluating imaging biomarkers in a clinical setting, including the distinction between diagnostic and prognostic biomarkers and the importance of assessing clinical utility within a multivariable model. The article emphasizes the need for adequate representative data to avoid underpowering and overfitting, and offers advice on how to report research accurately.

EUROPEAN RADIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging