期刊
RADIATION AND ENVIRONMENTAL BIOPHYSICS
卷 61, 期 1, 页码 169-175出版社
SPRINGER
DOI: 10.1007/s00411-021-00948-0
关键词
Cancer physics; Cancer transformation; Neoplastic transformation; Modeling; Avrami equation; Phase transition; Gastric cancer
The Avrami equation, originally used in condensed matter physics to describe crystallization and nucleation processes, is applied to cancer physics to enhance the multi-hit model of carcinogenesis. This approach considers the cancer transformation as a volumetric process of single cell's DNA neoplastic transformation, with the probability function directly related to the number of oncogenic mutations. The proposed model provides a different perspective on multi-hit carcinogenesis and is tested on clinical data for gastric cancer, showing a relationship between cancer transformation and DNA fractal geometry.
The nucleation and growth theory, described by the Avrami equation (also called Johnson-Mehl-Avrami-Kolmogorov equation), and usually used to describe crystallization and nucleation processes in condensed matter physics, was applied in the present paper to cancer physics. This can enhance the popular multi-hit model of carcinogenesis to volumetric processes of single cell's DNA neoplastic transformation. The presented approach assumes the transforming system as a DNA chain including many oncogenic mutations. Finally, the probability function of the cell's cancer transformation is directly related to the number of oncogenic mutations. This creates a universal sigmoidal probability function of cancer transformation of single cells, as observed in the kinetics of nucleation and growth, a special case of a phase transition process. The proposed model, which represents a different view on the multi-hit carcinogenesis approach, is tested on clinical data concerning gastric cancer. The results also show that cancer transformation follows DNA fractal geometry.
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