4.7 Article

Polygenic risk, familial liability and stress reactivity in psychosis: an experience sampling study

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A polygenic resilience score moderates the genetic risk for schizophrenia

Jonathan L. Hess et al.

Summary: This study proposed a theoretical framework based on genetic variations that promote resilience to highly heritable polygenic disorders, such as schizophrenia. By establishing a procedure to identify unaffected individuals with relatively high polygenic risk for the disease and generating the first known polygenic resilience score, this work laid a foundation for finding resilience variants for any complex, heritable disorder.

MOLECULAR PSYCHIATRY (2021)

Article Psychology, Developmental

Bullying victimization and stress sensitivity in help-seeking youth: findings from an experience sampling study

Christian Rauschenberg et al.

Summary: The study found that exposure to high levels of bullying victimization leads to more intense negative affect and psychotic experiences in response to stress for youth, while the control group showed no significant differences. This suggests that stress sensitivity may be a potential risk and resilience mechanism linking bullying victimization and youth mental health.

EUROPEAN CHILD & ADOLESCENT PSYCHIATRY (2021)

Review Psychiatry

From Basic Science to Clinical Application of Polygenic Risk Scores A Primer

Naomi R. Wray et al.

Summary: Polygenic risk scores (PRS) are predictors of genetic susceptibilities to diseases, calculated based on weighted counts of risk variants identified through genome-wide association studies. While PRS can be calculated from saliva or blood samples using inexpensive genotyping technologies, they may not definitively predict future diagnoses due to genetic factors only contributing partly to the risk. PRS could have utility in community settings or contribute to clinical decision-making, but more data are needed to develop their role in treatment choices.

JAMA PSYCHIATRY (2021)

Article Psychiatry

Social isolation, mental health, and use of digital interventions in youth during the COVID-19 pandemic: A nationally representative survey

Christian Rauschenberg et al.

Summary: Research shows that public health measures to curb SARS-CoV-2 transmission rates may negatively impact the mental health of youth, with evidence of associations between social isolation, COVID-19-related cognitive preoccupation, worries, anxiety, and psychological distress. Digital interventions, such as mHealth, may help mitigate these negative psychosocial effects among youth by promoting positive attitudes and actual usage.

EUROPEAN PSYCHIATRY (2021)

Review Health Care Sciences & Services

Evidence Synthesis of Digital Interventions to Mitigate the Negative Impact of the COVID-19 Pandemic on Public Mental Health: Rapid Meta-review

Christian Rauschenberg et al.

Summary: This study reviewed the theoretical and empirical base, user perspective, safety, effectiveness, and cost-effectiveness of digital interventions related to public mental health. The findings suggest good evidence on eHealth interventions and promising evidence on mHealth apps, with limited evidence on long-term effects and cost-effectiveness. Digital interventions are seen as particularly well-suited for mitigating psychosocial consequences at the population level during times of physical distancing and social restrictions.

JOURNAL OF MEDICAL INTERNET RESEARCH (2021)

Article Health Care Sciences & Services

Effects of a Novel, Transdiagnostic, Hybrid Ecological Momentary Intervention for Improving Resilience in Youth (EMlcompass): Protocol for an Exploratory Randomized Controlled Trial

Anita Schick et al.

Summary: This study aims to investigate a novel, transdiagnostic, hybrid ecological momentary intervention (EMI) for improving resilience to stress in youth. The study assesses primary and secondary candidate mechanisms, as well as primary and secondary outcomes related to psychological distress and psychiatric symptoms. Enrollments and randomizations have been completed, with data collection expected to be finished by August 2021.

JMIR RESEARCH PROTOCOLS (2021)

Review Health Policy & Services

A Systematic Review of Parent and Caregiver Mental Health Literacy

Diarmuid Hurley et al.

COMMUNITY MENTAL HEALTH JOURNAL (2020)

Article Psychology, Clinical

Redefining Phenotypes to Advance Psychiatric Genetics: Implications From Hierarchical Taxonomy of Psychopathology

Monika A. Waszczuk et al.

JOURNAL OF ABNORMAL PSYCHOLOGY (2020)

Meeting Abstract Clinical Neurology

GENOMIC DISSECTION OF BIPOLAR DISORDER AND SCHIZOPHRENIA IN 50K CASES, 50K CONTROLS AND 28 SUBPHENOTYPES

Douglas Ruderfer

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2019)

Meeting Abstract Clinical Neurology

GENOME-WIDE ANALYSES OF CLINICAL FEATURES OF SCHIZOPHRENIA IN THE PSYCHIATRIC GENOMICS CONSORTIUM

Tim Bigdeli et al.

EUROPEAN NEUROPSYCHOPHARMACOLOGY (2019)

Article Psychology, Clinical

Genetic risk scores and family history as predictors of schizophrenia in Nordic registers

Y. Lu et al.

PSYCHOLOGICAL MEDICINE (2018)

Article Genetics & Heredity

Genome-wide analysis of adolescent psychotic-like experiences shows genetic overlap with psychiatric disorders

Oliver Pain et al.

AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2018)

Article Genetics & Heredity

Next-generation genotype imputation service and methods

Sayantan Das et al.

NATURE GENETICS (2016)

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

Review Psychiatry

Gene-environment interactions in severe mental illness

Rudolf Uher

FRONTIERS IN PSYCHIATRY (2014)

Article Psychiatry

Urbanicity, social adversity and psychosis

Andreas Heinz et al.

WORLD PSYCHIATRY (2013)

Review Psychiatry

Social networks, support and early psychosis: a systematic review

C. Gayer-Anderson et al.

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES (2013)

Article Psychiatry

Childhood trauma and increased stress sensitivity in psychosis

M. Lardinois et al.

ACTA PSYCHIATRICA SCANDINAVICA (2011)

Article Psychiatry

Migration, Ethnicity, and Psychosis: Toward a Sociodevelopmental Model

Craig Morgan et al.

SCHIZOPHRENIA BULLETIN (2010)

Article Psychology, Clinical

Momentary Assessment Research in Psychosis

Margreet Oorschot et al.

PSYCHOLOGICAL ASSESSMENT (2009)

Article Genetics & Heredity

PLINK: A tool set for whole-genome association and population-based linkage analyses

Shaun Purcell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2007)

Review Psychology, Clinical

Stress-reactivity in psychosis: Evidence for an affective pathway to psychosis

Inez Myin-Germeys et al.

CLINICAL PSYCHOLOGY REVIEW (2007)

Review Psychology, Developmental

Gene-environment interplay and psychopathology: multiple varieties but real effects

M Rutter et al.

JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY (2006)

Article Psychiatry

Schizophrenia as a complex trait - Evidence from a meta-analysis of twin studies

PF Sullivan et al.

ARCHIVES OF GENERAL PSYCHIATRY (2003)

Article Psychiatry

Emotional reactivity to daily life stress in psychosis

I Myin-Germeys et al.

ARCHIVES OF GENERAL PSYCHIATRY (2001)