期刊
PSYCHIATRY RESEARCH-NEUROIMAGING
卷 319, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.pscychresns.2021.111419
关键词
Mindfulness; Posterior cingulate cortex; Dorsolateral prefrontal cortex; Attention
资金
- National Institutes of Mental Health [1K23MH074895]
- National Institute of Neurological Disorders and Stroke (NINDS) Training Program in Recovery and Restoration of CNS Health and Function [T32 NS100663]
- Tiny Blue Dot Foundation
Individuals with bipolar disorder show abnormalities in the default mode network and task positive network connectivity, which can be restored by mindfulness-based cognitive therapy.
Individuals with bipolar disorder (BP) show abnormalities in the default mode network (DMN), a brain network active at rest and during self-referential cognition. In healthy individuals, the DMN is anti-correlated (strongly negatively correlated) with the task positive network (TPN), a brain network that is active during attention demanding tasks. Mindfulness has been linked to changes in DMN connectivity. We investigated the effects of mindfulness-based cognitive therapy (MBCT) versus supportive psychotherapy (SP) on the relationship between these two networks in individuals with BP. We identified differences in BOLD resting state DMN-TPN connectivity between healthy controls (HC; n = 22) and individuals with DSM-IV BP before treatment (n = 22) using a seed region in the dorsolateral prefrontal cortex (DLPFC), a key TPN node. We then explored changes in DMNTPN connectivity after 12 weeks of MBCT or SP. Before treatment, BP individuals showed positively correlated activity and the HC group showed negatively correlated activity between the DLPFC and the posterior cingulate cortex (PCC). After treatment, BP individuals who received MBCT showed negatively correlated DLPFC-PCC activity. BP individuals who received SP did not show a significant change. Mindfulness-based cognitive therapy can restore the anti-correlation between the DMN and TPN in individuals with BP.
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