期刊
PSYCHIATRY RESEARCH
卷 305, 期 -, 页码 -出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.psychres.2021.114202
关键词
Major depressive disorder; Cognition; Inflammatory cytokines; Treatment response
类别
资金
- National Key R&D Program of China [2018YFC1314200]
- National Key Basic Research Program of China (973 program) [2013CB531305]
Inflammation and cognition are related to major depressive disorder (MDD). Treatment response in MDD patients is associated with different cognitive defects, especially in speed of processing and executive function. Factors such as smoking, alcohol drinking, baseline cognitive performance, and cytokine levels may influence treatment response.
Background: Inflammation and cognition are related to major depressive disorder (MDD), but the role in treatment response remains unclear. In this study, we investigated correlation between inflammatory cytokines and cognition in MDD patients treated with antidepressant medication. Methods: The participants were 149 MDD patients. Cytokines before therapy, cognitive assessments and severity of depression before and after therapy were tested. Logistic regression was used to explore underlying risks treatment response. Results: There were significant differences in smoking, alcohol drinking, and Stroop Color Test(SCT), Stroop Color-Word Test (SCWT), and Continuous Performance Test(CPT) scores between response group (RG) and nonresponse group (NRG) at baseline. Performance of patients in RG improved more in Brief Assessment of Cognition in Schizophrenia (BACS), Color Trial Test-I (CTT-I), SCT and SCWT after treatment. Levels of baseline IL-18 were associated with baseline learning and memory, and executive function. Treatment response was associated with drinking, performance of CPT and SCT. Conclusion: MDD patients with different treatment responses have different cognitive defects, especially in speed of processing and executive function. Expression of cytokines is associated with cognition and may influence treatment response. Better speed of processing and executive function, and poorer attention at baseline may respond better to antidepressant treatment.
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