Assessing the accuracy of contact and distance predictions in CASP14

We present the results of the assessment of the intramolecular residue-residue contact and distance predictions from groups participating in the 14th round of the CASP experiment. The performance of contact prediction methods was evaluated with the measures used in previous CASPs, while distance predictions were assessed based on a new protocol, which considers individual distance pairs as well as the whole predicted distance matrix, using a graph-based framework. The results of the evaluation indicate that predictions by the tFold framework, TripletRes and DeepPotential were the most accurate in both categories. With regards to progress in method performance, the results of the assessment in contact prediction did not reveal any discernible difference when compared to CASP13. Arguably, this could be due to CASP14 FM targets being more challenging than ever before.

Automated summary

The study evaluated the performance of groups in intramolecular residue-residue contact and distance predictions in the 14th round of the CASP experiment. The results showed that predictions by the tFold framework, TripletRes, and DeepPotential were the most accurate in both categories. Additionally, there was no discernible difference in contact prediction performance compared to CASP13, possibly due to the increased difficulty of the CASP14 FM targets.