期刊
PROTEIN SCIENCE
卷 31, 期 1, 页码 301-307出版社
WILEY
DOI: 10.1002/pro.4240
关键词
dissociation constant; protein-ligand interactions; relaxation dispersion; titration
PLIS is an open-source software for determination of protein-ligand dissociation constants, which can be used to characterize biological processes or to shed light on biophysical aspects of interactions. In addition to analyzing experimental data, PLIS includes functionality for generating synthetic data, useful for understanding how different parameters affect the data in order to better analyze experiments.
We present PLIS, a publicly available, open-source software for the determination of protein-ligand dissociation constants that can be used to characterize biological processes or to shed light on biophysical aspects of interactions. PLIS can analyze data from titration experiments monitored by for instance fluorescence spectroscopy or from nuclear magnetic resonance relaxation dispersion experiments. In addition to analysis of experimental data, PLIS includes functionality for generation of synthetic data, useful for understanding how different parameters effect the data in order to better analyze experiments.
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