期刊
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS
卷 177, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.plefa.2022.102401
关键词
Omega-3 fatty acids; Dose-response-relationship; Dietary biomarkers; Cancer; Acute lymphoblastic leukemia; Children
Long-chain n-3 fatty acids may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia. Compliance and intake-biomarker correlations are affected by bodyweight and blood transfusions. Relative blood content of n-3 LCPUFA reflects fish oil compliance in children with ALL, regardless of blood transfusions and differences in bodyweight.
Long-chain n-3 fatty acids (n-3 LCPUFA) may prevent chemotherapy-induced hyperlipidemia in children with acute lymphoblastic leukemia (ALL). However, compliance could be a problem and intake-biomarker correlations may be affected by bodyweight and blood transfusions. We assessed whole blood n-3 LCPUFA three times during the first 83 days of treatment in six 1-17-year-old children with ALL, who received 2.4-4.9 g/d n-3 LCPUFA depending on bodyweight. Mean compliance was 73%, which resulted in a 2.5-fold increase in blood n-3 LCPUFA irrespective of blood transfusions. The correlation between relative blood content of n-3 LCPUFA and intake in g/d across the study period was strong (r=0.76, p=0.001). When n-3 LCPUFA was expressed in absolute concentrations and intake per kg bodyweight the correlation decreased (r=0.39, p=0.164) and was driven by baseline values. Thus, relative content of n-3 LCPUFA in blood reflects fish oil compliance in children with ALL despite blood transfusions and differences in bodyweight.
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