4.2 Article

Influential role of 7-Ketocholesterol in the progression of Alzheimer’s disease

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Summary: Ergothioneine (ET) has a protective effect on human brain endothelial cells, reducing apoptosis, necrosis, and inflammation induced by 7-ketocholesterol (7KC). ET exerts its anti-inflammatory effects by reducing the expression of pro-inflammatory cytokines IL-1beta, IL-6, IL-8, TNF-alpha, and cyclooxygenase-2 (COX2).

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