期刊
PROGRESS IN NEUROBIOLOGY
卷 209, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.pneurobio.2021.102185
关键词
Posterior parietal cortex; Human; Macaque; Functional homology; Intraparietal area; VIP; Cross-species; Cortical expansion
资金
- German Research Foundation (DFG) [He 6368/4-1, ANR-18-CE92-0048]
- French National Research Agency (ANR) [He 6368/4-1, ANR-18-CE92-0048]
- Universite de Lyon from the programme Investissements d'Avenir [ANR-11-LABX-0042, ANR-11-IDEX-0007]
- Agence Nationale de la Recherche (ANR) [ANR-18-CE92-0048] Funding Source: Agence Nationale de la Recherche (ANR)
The paper reviews the important role of macaque VIP in sensorimotor and cognitive functions and integrates human studies, revealing three homologous structures of human VIP that are different in functionality from macaque VIP.
The macaque ventral intraparietal area (VIP) in the fundus of the intraparietal sulcus has been implicated in a diverse range of sensorimotor and cognitive functions such as motion processing, multisensory integration, processing of head peripersonal space, defensive behavior, and numerosity coding. Here, we exhaustively review macaque VIP function, cytoarchitectonics, and anatomical connectivity and integrate it with human studies that have attempted to identify a potential human VIP homologue. We show that human VIP research has consistently identified three, rather than one, bilateral parietal areas that each appear to subsume some, but not all, of the macaque area's functionality. Available evidence suggests that this human VIP complex has evolved as an expansion of the macaque area, but that some precursory specialization within macaque VIP has been previously overlooked. The three human areas are dominated, roughly, by coding the head or self in the environment, visual heading direction, and the peripersonal environment around the head, respectively. A unifying functional principle may be best described as prediction in space and time, linking VIP to state estimation as a key parietal sensorimotor function. VIP's expansive differentiation of head and self-related processing may have been key in the emergence of human bodily self-consciousness.
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