4.7 Review

Reactive astrocytes prevent maladaptive plasticity after ischemic stroke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Clinical Neurology

Lesion Size- and Location-Dependent Recruitment of Contralesional Thalamus and Motor Cortex Facilitates Recovery after Stroke in Mice

Markus Aswendt et al.

Summary: Brain lesions caused by cerebral ischemia or hemorrhage lead to local energy imbalance, cell death, and long-term impairment. These lesions also cause remote functional and structural disturbances, impacting recovery. Increased structural connectivity between brain regions is associated with lesion size and contralesional involvement, which is linked to better functional recovery.

TRANSLATIONAL STROKE RESEARCH (2021)

Review Neurosciences

Reactive astrocyte nomenclature, definitions, and future directions

Carole Escartin et al.

Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.

NATURE NEUROSCIENCE (2021)

Article Cell Biology

Reactive astrocytes facilitate vascular repair and remodeling after stroke

Michael R. Williamson et al.

Summary: This study demonstrates that reactive astrocytes play a crucial role in vascular repair and remodeling after ischemic stroke in mice, by activating transcriptional programs related to vascular remodeling. Ablation of reactive astrocytes significantly impairs vascular and extracellular matrix remodeling, leading to prolonged blood flow deficits, exacerbated vascular permeability, ongoing cell death, and worsened motor recovery. These findings highlight the critical role of reactive astrocytes as cellular mediators of vascular remodeling during neural repair.

CELL REPORTS (2021)

Review Biochemistry & Molecular Biology

Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury

Marcela Pekna et al.

Summary: Ischemic stroke and hypoxic-ischemic encephalopathy are major causes of neurological disability. While plasticity responses in spared brain regions contribute to functional recovery after brain injury, secondary neurodegeneration in remote regions can hinder long-term outcomes. The C3a receptor signaling plays a dual role in the acute and chronic phases after ischemic injury, with the potential for therapeutic modulation to improve outcomes.

NEUROCHEMICAL RESEARCH (2021)

Review Endocrinology & Metabolism

Post-stroke remodeling processes in animal models and humans

Carla Cirillo et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

Review Mathematical & Computational Biology

Animal Functional Magnetic Resonance Imaging: Trends and Path Toward Standardization

Francesca Mandino et al.

FRONTIERS IN NEUROINFORMATICS (2020)

Article Neurosciences

Astrocyte activation and reactive gliosis-A new target in stroke?

Milos Pekny et al.

NEUROSCIENCE LETTERS (2019)

Article Mathematical & Computational Biology

Processing Pipeline for Atlas-Based Imaging Data Analysis of Structural and Functional Mouse Brain MRI (AIDAmri)

Niklas Pallast et al.

FRONTIERS IN NEUROINFORMATICS (2019)

Review Physiology

PHYSIOLOGY OF ASTROGLIA

Alexei Verkhratsky et al.

PHYSIOLOGICAL REVIEWS (2018)

Review Behavioral Sciences

Behavioral outcome measures to improve experimental stroke research

Mustafa G. Balkaya et al.

BEHAVIOURAL BRAIN RESEARCH (2018)

Article Mathematical & Computational Biology

Cloud-based relational database for multimodal animal data

Niklas Pallast et al.

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION (2018)

Review Endocrinology & Metabolism

The IMPROVE Guidelines (Ischaemia Models: Procedural Refinements Of in Vivo Experiments)

Nathalie Percie du Sert et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2017)

Review Clinical Neurology

Astrocytes: a central element in neurological diseases

Milos Pekny et al.

ACTA NEUROPATHOLOGICA (2016)

Article Neurosciences

GDF10 is a signal for axonal sprouting and functional recovery after stroke

Songlin Li et al.

NATURE NEUROSCIENCE (2015)

Article Multidisciplinary Sciences

Paw-Dragging: a Novel, Sensitive Analysis of the Mouse Cylinder Test

R. Brian Roome et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Review Physiology

ASTROCYTE REACTIVITY AND REACTIVE ASTROGLIOSIS: COSTS AND BENEFITS

Milos Pekny et al.

PHYSIOLOGICAL REVIEWS (2014)

Article Clinical Neurology

Longitudinal Evaluation of Resting-State fMRI After Acute Stroke With Hemiparesis

Ali-Mohammad Golestani et al.

NEUROREHABILITATION AND NEURAL REPAIR (2013)

Article Multidisciplinary Sciences

A role for ephrin-A5 in axonal sprouting, recovery, and activity-dependent plasticity after stroke

Justine J. Overman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Article Cell & Tissue Engineering

Astrocytes Negatively Regulate Neurogenesis Through the Jagged1-Mediated Notch Pathway

Ulrika Wilhelmsson et al.

STEM CELLS (2012)

Review Clinical Neurology

Modulation of Neural Plasticity as a Basis for Stroke Rehabilitation

Marcela Pekna et al.

STROKE (2012)

Article Pharmacology & Pharmacy

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

Carol Kilkenny et al.

BRITISH JOURNAL OF PHARMACOLOGY (2010)

Article Multidisciplinary Sciences

Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke

Andrew N. Clarkson et al.

NATURE (2010)

Article Neurosciences

Complex network measures of brain connectivity: Uses and interpretations

Mikail Rubinov et al.

NEUROIMAGE (2010)

Review Neurosciences

Plasticity during stroke recovery: from synapse to behaviour

Timothy H. Murphy et al.

NATURE REVIEWS NEUROSCIENCE (2009)

Article Neurosciences

Longitudinal in vivo MRI of alterations in perilesional tissue after transient ischemic stroke in rats

Jet P. van der Zijden et al.

EXPERIMENTAL NEUROLOGY (2008)

Article Endocrinology & Metabolism

Thrombospondins 1 and 2 are necessary for synaptic plasticity and functional recovery after stroke

Jason Liauw et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Endocrinology & Metabolism

Manganese-enhanced MRI of brain plasticity in relation to functional recovery after experimental stroke

Jet P. van der Zijden et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Endocrinology & Metabolism

Protective role of reactive astrocytes in brain ischemia

Lizhen Li et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2008)

Article Multidisciplinary Sciences

Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury

Ulrika Wilhelmsson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

Astrocyte activation and reactive gliosis

M Pekny et al.

Article Biochemistry & Molecular Biology

Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis

KS Christopherson et al.

Article Multidisciplinary Sciences

Axonal plasticity and functional recovery after spinal cord injury in mice deficient in both glial fibrillary acidic protein and vimentin genes

V Menet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biochemistry & Molecular Biology

Intermediate filaments regulate astrocyte motility

EA Lepekhin et al.

JOURNAL OF NEUROCHEMISTRY (2001)