期刊
INORGANIC CHEMISTRY
卷 55, 期 20, 页码 10267-10277出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.6b01522
关键词
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资金
- Ministry of Science and Technology of Taiwan [MOST 104-2113-M-002-012-MY3, MOST 104-0210-01-09-02, MOST 105-0210-01-13-01]
- NSFC [U1305244, 21325104]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- Molecular Imaging Center of National Taiwan University
- National Center for High Performance Computing, Taiwan
- Research Center for Applied Sciences, Academia Sinica, Taiwan
Photodynamic therapy (PDT) is a promising antitumor treatment that is based on photosensitizers. This therapy kills cancer cells by generating reactive oxygen species (ROS) after irradiation with specific laser wavelengths. Being a potential photosensitizer, graphitic carbon nitride (g-C3N4) quantum dots (QDs) are noncytotoxic. Although: the use of g-C3N4 QDs is challenged by the limited tissue penetration of UV light, g-C3N4 QDs display excellent ultraviolet (UV) light-triggered cytotoxicity. The g-C3N4 QDs were synthesized using a solid-phase hydrothermal method.. The well-distributed hydrophilic gC(3)N(4) can be combined with NaYF4:Yb3+/Tm3+ upconversion nanoparticles via the positive ligand poly(L-lysine) to produce the final nanocomposite, NaYF4:Yb/Tm-PLL@g-C3N4. Upconversion nanoparticles can transfer IR light into UV light and promote g-C3N4, to release blue-to-green visible light to generate different images. Moreover, g-C3N4 is a promising photosensitizer in PDT because g-C3N4 can transfer oxygen into toxic ROS. The singlet oxygen formed by g-C3N4 displays great potential for use in the treatment of cancer.
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