期刊
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
卷 289, 期 1967, 页码 -出版社
ROYAL SOC
DOI: 10.1098/rspb.2021.2155
关键词
parasite; co-infection; trypanosoma; plasmodium
资金
- Wellcome Trust [221 717/Z/20/Z, 206815/Z/17/Z, 103740/Z/14/Z]
- Wellcome Trust PhD studentship on the University of Edinburgh Wellcome Trust 'Hosts, Pathogens and Global Health' Programme [108905/Z/15/Z]
- Wellcome Trust [206815/Z/17/Z] Funding Source: Wellcome Trust
Laboratory studies of pathogens often overlook the interactions between pathogens and hosts, despite the fact that hosts frequently sustain co-infections with multiple pathogens. These interactions between co-infecting pathogens and the host immune system are complex and can greatly affect disease outcomes. Researchers have used ecological and experimental studies of trypanosome and malaria infections to examine these interactions.
Laboratory studies of pathogens aim to limit complexity in order to disentangle the important parameters contributing to an infection. However, pathogens rarely exist in isolation, and hosts may sustain co-infections with multiple disease agents. These interact with each other and with the host immune system dynamically, with disease outcomes affected by the composition of the community of infecting pathogens, their order of colonization, competition for niches and nutrients, and immune modulation. While pathogen-immune interactions have been detailed elsewhere, here we examine the use of ecological and experimental studies of trypanosome and malaria infections to discuss the interactions between pathogens in mammal hosts and arthropod vectors, including recently developed laboratory models for co-infection. The implications of pathogen co-infection for disease therapy are also discussed.
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