4.8 Article

MEKK3-TGFβ crosstalk regulates inward arterial remodeling

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Activation of Smad2/3 signaling by low fluid shear stress mediates artery inward remodeling

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Summary: This study investigates the sensing of fluid shear stress by endothelial cells. Low shear stress triggers inward remodeling to restore normal levels, while high shear stress is suppressed. The findings suggest that low shear stress activates the Smad2/3 pathway, while high shear stress blocks Smad2/3 nuclear translocation.

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