Synthesis of an Enantipure Tetrazole-Based Homochiral CuI,II-MOF for Enantioselective Separation

An enantipure (1S)-1-(5-tetrazolyl)-ethylamine (5-eatz) ligand was first employed to construct a homochiral porous metal-organic framework, {[(Cu2CuII)-Cu-I(5-eatz)(2)(CN-)(H2O)](+)[NO3-]}center dot[DMF] (1), with unusual ligand-unsupported Cu center dot center dot center dot Cu interactions. Such a compound shows high stability in water and common organic solvents. Remarkably, it has high enantioselectivity toward (R,S)-1-phenylethanol and (R,S)-1-phenylpropanol with enantiomeric excess values of up to 42% and 48%, respectively.