期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2111409119
关键词
p53; lncRNA; CPEB2; translation; tumorigenesis
资金
- Ministry of Science and Technology of China [2019YFA0802600]
- National Natural Science Foundation of China [91957108, 31871440]
- Collaborative Innovation Programs of Hefei Science Center, Chinese Academy of Sciences [2019HSC-CIP010]
- Fundamental Research Funds for Central Universities [YD9100002012, WK9100000024, YD2070002007]
This study reveals a mutual repression between p53 and lncRNA E2F1 messenger RNA stabilizing factor (EMS) in tumor suppression. EMS inhibits p53 expression by disrupting the CPEB2-p53 mRNA interaction, leading to a suppression of p53 translation. EMS plays a critical role in promoting tumorigenesis through negative regulation of p53.
p53 plays a central role in tumor suppression. Emerging evidence suggests long noncoding RNA (lncRNA) as an important class of regulatory molecules that control the p53 signaling. Here, we report that the oncogenic lncRNA E2F1 messenger RNA (mRNA) stabilizing factor (EMS) and p53 mutually repress each other's expression. EMS is negatively regulated by p53. As a direct transcriptional repression target of p53, EMS is surprisingly shown to inhibit p53 expression. EMS associates with cytoplasmic polyadenylation element-binding protein 2 (CPEB2) and thus, disrupts the CPEB2-p53 mRNA interaction. This disassociation attenuates CPEB2-mediated p53 mRNA polyadenylation and suppresses p53 translation. Functionally, EMS is able to exert its oncogenic activities, at least partially, via the CPEB2-p53 axis. Together, these findings reveal a double-negative feedback loop between p53 and EMS, through which p53 is finely controlled. Our study also demonstrates a critical role for EMS in promoting tumorigenesis via the negative regulation of p53.
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