期刊
INORGANIC CHEMISTRY
卷 55, 期 22, 页码 11639-11643出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.inorgchem.6b02560
关键词
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资金
- Wellcome Trust [092506, 098335]
[IrCl(COE)(2)](2) (1) reacts with pyridine (py) and H-2 to form crystallographically characterized IrCl(H)(2)(COE)(py)(2) (2). 2 undergoes py loss to form 16 electron IrCI(H)(2)(COE)(py) (3), with equivalent hydride ligands. When this reaction is studied with parahydrogen, 1 efficiently achieves hyperpolarization of free py (and nicotinamide, nicotine, 5-aminopyrimidine, and 3,5-lutudine) via signal amplification by reversible exchange (SABRE) and hence reflects a simple and readily available precatayst for this process. 2 reacts further over 48 h at 298 K to form crystallographically characterized (Cl) (H) (py)(mu-Cl)(mu-H)(kappa-mu-NC5H4)Ir(H)(py)(2) (4). This dimer is active in the hydrogen isotope exchange process that is used in radiopharmaceutical preparations. Furthermore, while [Ir(H)(2)(COE)(py)(3)]PF6 (6) forms upon the addition of AgPF6 to 2, its stability precludes its efficient involvement in SABRE.
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