4.8 Article

IP3R-driven increases in mitochondrial Ca2+promote neuronal death in NPC disease

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Summary: The research revealed the significant role of calcium in controlling cholesterol export at membrane contact sites between the endoplasmic reticulum and Golgi, mediated by INPP5A through IP3 hydrolysis. This finding is important for understanding the lipid exchange at membrane contact sites between different organelles and its regulatory mechanisms.

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