期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2111193118
关键词
artificial self-replication; mutation; Darwinian evolution; exponential growth; cross-tile DNA origami
资金
- Department of Energy (DOE) [DE-SC0007991]
- Center for Bio-Inspired Energy Sciences, an Energy Frontier Research Center - DOE, Office of Sciences, Basic Energy Sciences [DE-SC0000989]
- Army Research Office [MURI N000140911118]
- Office of Naval Research [MURI N000140911118]
- Human Frontiers Science Program [RGP0010/2017]
- DOE [DE-SC0007991]
- NSF [EFRI-1332411, CCF-1526650, DMR-1420073]
- MRSEC programof the NSF [DMR-1420073]
- U.S. Department of Energy (DOE) [DE-SC0007991] Funding Source: U.S. Department of Energy (DOE)
Artificial self-replication and exponential growth have the potential to aid in better understanding fundamental processes in nature and developing new materials and devices. By introducing mutation and growth advantages in a system of DNA origami dimers, researchers have demonstrated a Darwinian-like evolution. Through controlled mutation rates and growth advantages, a new species can take over the system in a relatively short amount of time.
Artificial self-replication and exponential growth holds the promise of gaining a better understanding of fundamental processes in nature but also of evolving new materials and devices with useful properties. A system of DNA origami dimers has been shown to exhibit exponential growth and selection. Here we introduce mutation and growth advantages to study the possibility of Darwinian-like evolution. We seed and grow one dimer species, AB, from A and B monomers that doubles in each cycle. A similar species from C and D monomers can replicate at a controlled growth rate of two or four per cycle but is unseeded. Introducing a small mutation rate so that AB parents infrequently template CD offspring we show experimentally that the CD species can take over the system in approximately six generations in an advantageous environment. This demonstration opens the door to the use of evolution in materials design.
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