期刊
出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.2118799119
关键词
X-ray small-angle scattering; X-ray imaging dark-field imaging computed tomography Talbot-Lau interferometry
资金
- Karlsruhe Nano Micro Facility, Helmholtz Research Infrastructure at the Karlsruhe Institute of Technology
- Technical University of Munich Institute for Advanced Study - German Excellence Initiative
- European Research Council [695045]
- Philips GmbH Market DACH
- European Research Council (ERC) [695045] Funding Source: European Research Council (ERC)
X-ray computed tomography (CT) is a commonly used three-dimensional medical imaging technique. Dark-field imaging offers complementary information on tissue microstructure. However, translating dark-field CT to human scale has been a challenge. In this study, the integration of a Talbot-Lau interferometer into a clinical CT gantry enables successful dark-field CT imaging of a human-sized anthropomorphic body phantom.
X-ray computed tomography (CT) is one of the most commonly used three-dimensional medical imaging modalities today. It has been refined over several decades, with the most recent innovations including dual-energy and spectral photon-counting technologies. Nevertheless, it has been discovered that wave optical contrast mechanisms-beyond the presently used X-ray attenuation-offer the potential of complementary information, particularly on otherwise unresolved tissue microstructure. One such approach is dark-field imaging, which has recently been introduced and already demonstrated significantly improved radiological benefit in small-animal models, especially for lung diseases. Until now, however, dark-field CT could not yet be translated to the human scale and has been restricted to benchtop and small-animal systems, with scan durations of several minutes or more. This is mainly because the adaption and upscaling to the mechanical complexity, speed, and size of a human CT scanner so far remained an unsolved challenge. Here, we now report the successful integration of a Talbot-Lau interferometer into a clinical CT gantry and present dark-field CT results of a human sized anthropomorphic body phantom, reconstructed from a single rotation scan performed in 1 s. Moreover, we present our key hardware and software solutions to the previously unsolved roadblocks, which so far have kept dark-field CT from being translated from the optical bench into a rapidly rotating CT gantry, with all its associated challenges like vibrations, continuous rotation, and large field of view. This development enables clinical dark-field CT studies with human patients in the near future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据