Star-like poly(peptoid)s with selective antibacterial activity

We developed new macromolecular engineering approaches enabling the preparation of star-like polypeptoids by ring-opening polymerization. Parallely to the evaluation of their cytotoxicity of the HepG2 human cell line, their screening toward a wide variety of Gram-positive and Gram-negative bacteria higlighted several compounds showing not only good but also selective antimicrobial activity.

Automated summary

New macromolecular engineering approaches were developed to prepare star-like polypeptoids through ring-opening polymerization. Evaluation of their cytotoxicity on HepG2 human cell line and screening against a variety of Gram-positive and Gram-negative bacteria identified several compounds with both good and selective antimicrobial activity.