期刊
POLYMER CHEMISTRY
卷 13, 期 3, 页码 373-378出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d1py00947h
关键词
-
资金
- National Natural Science Foundation of China [21872085]
- innovation Project of Jinan Science and Technology Bureau [2020GXRC022]
- Project for Scientific Research Innovation Team of Young Scholar in Colleges and Universities of Shandong Province [2020KJC001]
This study demonstrates the synthesis of a bottlebrush block copolymer by ROMP for the fabrication of pH-responsive NPs containing a bortezomib prodrug. The cleavage of borate ester bonds in acidic pH environment leads to the release of bortezomib, showing effective inhibition of cell and tumor growth with minimal side effects.
Therapeutic nanoparticles (NPs) have shown their potential for biomedical applications (e.g., drug delivery). In this study, we report the synthesis of a bottlebrush block copolymer by ring opening metathesis polymerization (ROMP) and fabrication of pH-responsive NPs (denoted as BNPs) by self-assembly of an innovative bortezomib (BTZ) prodrug. The cleavage of borate ester bonds at acidic pH results in the release of BTZ from BNPs. Moreover, BNPs can inhibit cell and tumor growth without significant side effects.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据