4.5 Article

Interaction of water soluble cationic gallium(III) phthalocyanines with different G-quadruplex DNAs

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Investigation of Binding behaviour of a water-soluble gallium (III) phthalocyanine with double-stranded and G-quadruplex DNA via experimental and computational methods

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Summary: In this study, the affinity and binding mechanisms of water-soluble gallium phthalocyanine with DNA were investigated using various experimental techniques and computational studies. The results showed higher affinity of GaPc towards G-quadruplex DNA, leading to reduced aggregation of GaPc and conformational changes in the G-quadruplex DNA structure. Both experimental and computational findings indicated the potential of GaPc-G-quadruplex DNA conjugates for applications in photodynamic therapy.

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