Microwave-Assisted Chemistry: New Synthetic Application for the Rapid Construction of 1H-Pyrazolo[1,2-b]Phthalazine-5,10-Dione Derivatives in Diisopropyl Ethyl Ammonium Acetate

In the frame of research that examines the use of task-specific ionic liquids (ILs) for developing green methodologies toward bioactive substituted 1H-pyrazolo[1,2-b]phthalazine-5,10-diones derivatives via one-pot condensation of aldehydes, malononitrile and phthalhydrazide presence of Diisopropyl Ethyl Ammonium Acetate (DIPEAc-IL) as catalyst under conventional reflux as well as microwave irradiation condition. providing the desired product in very satisfactory yields (up to 94%) and high purity after simple workup. The task-specific ILs were recycled and reused four times without a noticeable decrease in their catalytic activity. Mild conditions with excellent conversions and simple product isolation procedures are noteworthy advantages of this method. The recyclability of the ionic liquid makes this protocol environmentally benign.

Automated summary

In this study, bioactive compounds were successfully synthesized using task-specific ionic liquids as catalysts. The method offers mild reaction conditions, high recyclability, and environmental friendliness.