4.3 Article

An Organocatalytic Newer Synthetic Approach toward the Access of Dihydropyrido[2,3-d] Pyrimidine in Water: A Perfect Synergy for Eco-compatible Organic Synthesis

期刊

POLYCYCLIC AROMATIC COMPOUNDS
卷 42, 期 10, 页码 7368-7384

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/10406638.2021.1998156

关键词

Multicomponent reaction; taurine; three-component reaction; organocatalysis; dihydropyrido[2; 3-d]pyrimidine

资金

  1. Council of Scientific and Industrial Research (CSIR), New Delhi

向作者/读者索取更多资源

A simple and effective protocol for synthesizing dihydropyrido[2,3-d]pyrimidine derivatives using 2-aminoethanesulfonic acid in water was presented. This method produced uracil annulated heterocycles with good to excellent yields, offering operational simplicity, easy workup, superior green credentials, and the ability to reuse the catalyst multiple times without significant loss in activity.
The simple and effective one-pot, three-component protocol for the synthesis of dihydropyrido[2,3-d]pyrimidine derivatives is presented using a 2-aminoethanesulfonic acid in water. Uracil annulated heterocycles were obtained using various aromatic/aliphatic aldehydes, 6-amino-1,3-dimethyl uracil, and acetyl acetone at 60-80 degrees C in 2-aminoethanesulfonic acid and water as a green reaction medium. The product obtained was in good to excellent yield (90-94%) in minimum reaction time. Operational simplicity, easy workup, Superior green credentials and the catalyst could be recovered and reused for four consecutive cycles without appreciable loss in catalytic activity.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.3
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据