4.6 Article

Nanoemulsions containing Garcinia mangostana L. pericarp extract for topical applications: Development, characterization, and in vitro percutaneous penetration assay

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PLOS ONE
卷 16, 期 12, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0261792

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  1. PUTI Q1 research scheme - Universitas Indonesia [NKB-1434/UN2.RST/HKP.05.00/2020]

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The study developed a highly stable oil-in-water nanoemulsion containing mangostins extracted from the pericarp of mangosteen, prepared using the low-energy emulsification method and stabilized with xanthan gum, showing high skin penetration in vitro. This nanoemulsion has potential for topical applications.
A highly stable oil-in-water nanoemulsion for topical applications, containing mangostins extracted from the pericarp of mangosteen (Garcinia mangostana L.), is a promising strategy to protect mangostins as well as to improve penetration of these important antioxidants through the skins. Nanoemulsions consisted of virgin coconut oil as the oil phase, Tween-80 and Span-80 as surfactants, and xanthan gum as the thickening agent, were prepared using the high-energy and low-energy emulsification methods. The nanoemulsions that were stable up to 28 days had oil droplet diameter of 220 nm to 353 nm and zeta potential of -46.9 mV to -63.7 mV. The accelerated stability test showed that the most stable nanoemulsions were those prepared using the low-energy emulsification method with an estimated shelf life of eleven months, composed of 11% oil phase, 17% surfactant, and 72% aqueous phase. The in vitro percutaneous penetration test for the nanoemulsion with added xanthan gum provided high cumulative skin penetration of mangostins of up to 114 mu g/cm(2). The results of this study indicate that virgin coconut oil-based nanoemulsions containing mangostins, prepared using the low-energy emulsification method, stabilized by xanthan gum and mixed at 40 degrees C can prospectively be used for topical applications.

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