Health risk assessment of exposure to chlorpyrifos in pregnant women using deterministic and probabilistic approaches

Since chlorpyrifos (CPF), a major organophosphorus pesticide, is widely used for agricultural and domestic purposes, thus, humans may be exposed to these toxic compounds through multiple sources. In recent years, significant concerns have been raised regarding the deleterious effects of exposure to CPF on human health, especially growing fetus. Therefore, in this study, we aimed to evaluate the health risks of exposure to CPF among pregnant women living in Isfahan province, Iran, using deterministic and probabilistic approaches. The urinary concentration of 3, 5, 6-trichloro-2-pyridinol (TCP), the most common metabolite of CPF, was measured as the biomarker of current exposure to CPF. For this purpose, spot urine samples were taken from 110 pregnant women and the urinary concentrations of TCP were quantified. The estimated daily intake and hazard quotient (HQ) for CPF exposure were measured according to the reference values set by World Health Organization (WHO) and United States Environmental Protection Agency (US EPA) for acute and chronic exposure to CPF. Based on the results, TCP was detected in more than 70% of samples (3.8 +/- 2.72 mu g/L). The estimated daily intake for some participants was found to be higher than the suggested reference dose by USEPA for chronic exposure to CPF. Furthermore, the HQ>1 was obtained for 20% of the study population in Monte-Carlo analysis using USEPA chronic reference dose, indicating that chronic toxic effects are expected at least for a part of the target population. Based on the findings, proper measures should be taken to reduce the exposure of Iranian pregnant women to CPF and resultant health risks.

Automated summary

This study aimed to evaluate the health risks of exposure to chlorpyrifos (CPF) among pregnant women in Isfahan province, Iran. The concentration of 3, 5, 6-trichloro-2-pyridinol (TCP), the major metabolite of CPF, was measured in urine samples from 110 pregnant women. TCP was detected in over 70% of the samples, indicating widespread exposure. The estimated daily intake of CPF exceeded the suggested reference dose for chronic exposure in some participants, and Monte-Carlo analysis revealed that chronic toxic effects are expected in at least 20% of the study population.