Source apportionment and quantification of liquid and headspace leaks from closed system drug-transfer devices via Selected Ion Flow Tube Mass Spectrometry (SIFT-MS)

A system to differentiate and quantify liquid and headspace vapor leaks from closed system drug-transfer devices (CSTDs) is presented. CSTDs are designed to reduce or eliminate hazardous drug (HD) exposure risk when compounding and administering HDs. CSTDs may leak liquid, headspace, or a mixture of the two. The amount of HD contained in liquid and headspace leaks may be substantially different. Use of a test solution containing two VOCs with differences in ratios of VOC concentrations in the headspace and liquid enables source apportionment of leaked material. SIFT-MS was used to detect VOCs from liquid and headspace leaks in the vapor phase. Included in this report is a novel method to determine the origin and magnitude of leaks from CSTDs. A limit of leak detection of 24 mu L of headspace vapor and 0.14 mu L of test liquid were found using Selected Ion Flow Tube Mass Spectrometry (SIFT-MS).

Automated summary

A system to differentiate and quantify liquid and headspace vapor leaks from closed system drug transfer devices is proposed, which uses a test solution with two VOCs and SIFT-MS to detect VOCs. The method allows for source apportionment of leaked material and has a limit of leak detection using SIFT-MS at 24 mu L of headspace vapor and 0.14 mu L of test liquid.