4.6 Article

Sex differences in the association of vitamin D and metabolic risk factors with carotid intima-media thickness in obese adolescents

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PLOS ONE
卷 16, 期 10, 页码 -

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PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0258617

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  1. Indonesian Pediatric Society
  2. Frisian Flag Indonesia [355/Legal/FFI/XII/2014]
  3. Indonesian Pediatric Association Committee
  4. Frisian Flag Indonesia

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The study found that hyperinsulinemia, higher total cholesterol, and LDL cholesterol were associated with increased CIMT among obese adolescent boys. In contrast, there was no association between vitamin D levels and CIMT, and none of the metabolic risk factors were associated with CIMT in girls.
Background It has been shown that vitamin D is associated with obesity and the development of atherosclerosis. Less is known about this association among adolescents with obesity. Objectives To determine the association of vitamin D level and metabolic risk factors with carotid intima-media thickness (CIMT) among obese adolescents. Methods We conducted a cross-sectional study among obese children aged 15 to 17 years in Yogyakarta, Indonesia. The association of vitamin D and other metabolic risk factors (triglyceride, low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), and insulin resistance using homeostasis model assessment of insulin resistance (HOMA-IR)) with CIMT was explored by multivariable linear regression models. Results Out of 156 obese adolescents, 55.8% were boys. Compared to girls, boys had higher BMI z-score, waist circumference, and HDL-cholesterol. After adjustment for age, sex and second-hand smoke exposure, high HOMA-IR, total cholesterol, LDL-cholesterol and triglyceride levels were associated with higher odds of elevated CIMT. In analyses stratified by sex, a similar trend was observed in boys, while none of the risk factors were associated with CIMT in girls. We observed no association between vitamin D and CIMT. Conclusions Hyperinsulinemia, higher total cholesterol and LDL cholesterol were associated with greater odds of elevated CIMT among obese adolescent boys.

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