期刊
PLOS ONE
卷 16, 期 10, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0245103
关键词
-
资金
- ELIXIR CZ research infrastructure project (Ministry of Youth, Education and Sports of the Czech Republic) [LM2018131]
This study collected data from 213 COVID-19 patients admitted to ten hospitals in Czech Republic, revealing weak evidence for the potential efficacy of azithromycin and favipiravir treatment. Additionally, the external validation of several proposed prognostic models for Covid-19 severity showed unsatisfactory performance on the dataset.
We collected a multi-centric retrospective dataset of patients (N = 213) who were admitted to ten hospitals in Czech Republic and tested positive for SARS-CoV-2 during the early phases of the pandemic in March-October 2020. The dataset contains baseline patient characteristics, breathing support required, pharmacological treatment received and multiple markers on daily resolution. Patients in the dataset were treated with hydroxychloroquine (N = 108), azithromycin (N = 72), favipiravir (N = 9), convalescent plasma (N = 7), dexamethasone (N = 4) and remdesivir (N = 3), often in combination. To explore association between treatments and patient outcomes we performed multiverse analysis, observing how the conclusions change between defensible choices of statistical model, predictors included in the model and other analytical degrees of freedom. Weak evidence to constrain the potential efficacy of azithromycin and favipiravir can be extracted from the data. Additionally, we performed external validation of several proposed prognostic models for Covid19 severity showing that they mostly perform unsatisfactorily on our dataset.
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