4.6 Article

Intranasal oxygen reverses hypoxaemia in immobilised free-ranging capybaras (Hydrochoerus hydrochaeris)

期刊

PLOS ONE
卷 16, 期 11, 页码 -

出版社

PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pone.0260441

关键词

-

资金

  1. Fundacao de Amparo a Pesquisa do Estado de Sao Paulo - FAPESP [2016/21121-9]

向作者/读者索取更多资源

The study found that different chemical restraint protocols did not affect blood variables in capybaras, but could lead to hypoxaemia. Nasal oxygen supplementation at 2 L/min after 30 min improved hypoxaemia, with 5 L/min being more efficient in treating it.
Capybara (Hydrochoerus hydrochaeris) is the main host of tick-borne pathogens causing Brazilian spotted fever; therefore, controlling its population is essential, and this may require chemical restraint. We assessed the impact of chemical restraint protocols on the partial pressure of arterial oxygen (PaO2) and other blood variables in 36 capybaras and the effect of different flows of nasal oxygen (O-2) supplementation. The capybaras were hand-injected with dexmedetomidine (5 mu g/kg) and midazolam (0.1 mg/kg) and butorphanol (0.2 mg/kg) (DMB, n = 18) or methadone (0.1 mg/kg) (DMM, n = 18). One-third of the animals were maintained in ambient air throughout the procedure, and one-third were administered intranasal 2 L/min O-2 after 30 min whereas the other third were administered 5 L/min O-2. Arterial blood gases, acid-base status, and electrolytes were assessed 30 and 60 min after drug injection. The DMB and DMM groups did not vary based on any of the evaluated variables. All animals developed hypoxaemia (PaO2 44 [30; 73] mmHg, SaO(2) 81 [62; 93] %) 30 min before O-2 supplementation. Intranasal O-2 at 2 L/min improved PaO2 (63 [49; 97] mmHg and SaO(2) [92 [85; 98] %), but 9 of 12 capybaras remained hypoxaemic. A higher O-2 flow of 5 L/min was efficient in treating hypoxaemia (PaO2 188 [146; 414] mmHg, SaO(2) 100 [99; 100] %) in all the 12 animals that received it. Both drug protocols induced hypoxaemia, which could be treated with intranasal oxygen supplementation.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据