期刊
PLASMA PROCESSES AND POLYMERS
卷 19, 期 6, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202100210
关键词
cold plasma; human osteosarcoma cells; plasma treatment; super resolution fluorescence microscopy; vesicle transport
资金
- 'Hundred Talents Program' of the 'Pioneer Initiative' in Chinese Academy of Sciences [Y722171202]
- National Key R&D Programs of China [2019YFC0119102, 2019YFC0118004, 2020YFC0122301]
Cold atmospheric plasma treatment has a significant impact on vesicle transport, causing disintegration of vesicle clusters and reducing transport velocity. Additionally, it inhibits vesicle transport between osteosarcoma cells and human bronchial epithelium.
Vesicle transport plays a key role in cancer invasion and metastasis. As a promising cancer treatment modality, the impact of cold atmospheric plasma (CAP) on vesicle transport has been barely examined. In this study, super-resolution structured illumination microscopy (SIM) was employed to track the intracellular vesicles of osteosarcoma cells. Results indicated that CAP exposure could disintegrate vesicle clusters and individual vesicles. After 20 s of CAP treatment, the average velocity of intracellular vesicles decreased from 0.140 to 0.037 mu m/s, while the 60 s maximum displacement declined from 7.76 to 3.26 mu m. Significant inhibition of vesicle transport between osteosarcoma cells and human bronchial epithelium was observed after CAP treatment. These findings may shed some light on understanding CAP-cancer cell interactions.
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