期刊
PLASMA PROCESSES AND POLYMERS
卷 19, 期 7, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ppap.202100244
关键词
biomimetic orthopaedic implant; bone; implant interface; osseointegration; poly(ether-ether-ketone) (PEEK); sheep model
资金
- Australian Government
- Ian Potter Foundation
- Sydney Local Health District
- Lang Walker Family Foundation
- Cancer Institute NSW
This study demonstrates that plasma immersion ion implantation enhances the adhesion of 3D printed PEEK material to bone tissue. Treated materials exhibit higher pull-off strength and torque in both in vitro and in vivo tests compared to untreated materials. The authors propose PIII-PEEK as a scaffold material with tensile properties similar to the fibrillar component of bone.
Adhesion of regenerating bone tissue to orthopaedic implants is critical to their long-term success. Titanium has excess rigidity, interferes with imaging, and complicates radiation treatment. Poly(ether-ether-ketone) (PEEK) is a preferred material, but is limited by biological inertness. We show that plasma immersion ion implantation (PIII) imparts osteoadhesion on 3D printed PEEK using in vitro pull-off tests and in vivo torque tests in a sheep scapula model. PIII-PEEK prints incubated with bone cells in vitro show 9-14 times higher pull-off strength, compared to untreated implants. Treated implants in vivo require seven times higher torque for release from the sheep scapula. We propose PIII-PEEK as a scaffold material with tensile properties analogous to collagen, the fibrillar component of bone, to produce fracture-tough fully integrating scaffolds.
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