期刊
PLANTA MEDICA
卷 88, 期 13, 页码 1190-1198出版社
GEORG THIEME VERLAG KG
DOI: 10.1055/a-1716-0958
关键词
Malus rockii; Rosaceae; phloridzin; hypolipidemic activity; antimalarial activity; analgesic activity
资金
- National Natural Science Foundation of China [81960637, 81641187]
- Yunnan Key Laboratory of Screening and Research on Anti-pathogenic Plant Resources from Western Yunnan (Cultivation) [202105AG070003]
- Special Basic Cooperative Research Programs of Yunnan Provincial Undergraduate Universities' Association [2019FH001-050]
- Scientific Research Initiation Fund of Dali University for Doctor [KYBS201734]
- Innovation Team Project of Dali University for Development and Utilization of Characteristic Medicinal Plants in Western Yunnan & Bai Nationality Medicines [ZKLX2019106]
The study found that phloridzin highly accumulated in the Malus rockii Rehder plant, exhibiting significant hypolipidemic activity and moderate antimalarial and analgesic activities.
Phloridzin is a lead compound of the prestigious antidiabetic gliflozins. The present study found that phloridzin highly accumulated in Malus rockii Rehder. The content of phloridzin in M. rockii was the highest among wild plants, with the percentage of 15.54% in the dry leaves. The structure of phloridzin was revised by proton exchange experiments and extensive 2D NMR spectra. Phloridzin exhibited significant hypolipidemic activity in golden Syrian hamsters maybe by increasing the expression of CYP7A1, at the doses of 50 mg/kg and 200 mg/kg. The total performance of anti-hyperlipidemic effect of phloridzin may be superior to that of lovastatin, though lovastatin was more active than phloridzin. In addition, phloridzin exhibited moderate antimalarial activity with inhibition ratio of 31.3 +/- 10.9% at a dose of 25 mg/kg/day, and showed moderate analgesic activity with 28.0% inhibition at a dose of 50 mg/kg.
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