4.5 Article

Raw and Wine Processed Schisandra chinensis Regulate NREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by Modulating HPA Axis

期刊

PLANTA MEDICA
卷 88, 期 14, 页码 1311-1324

出版社

GEORG THIEME VERLAG KG
DOI: 10.1055/a-1721-4971

关键词

insomnia; cardiovascular system; HPA axis; neurotransmitters; Schisandra chinensis; Schisandraceae

资金

  1. Jiangxi Provincial Natural Science Foundation [20212BAB206012, 20202BABL206142]
  2. National Natural Science Foundation of China [81860702, 82060808, 82074014]
  3. Science and Technology Key Project of Jiangxi Provincial Department of Education [GJJ201206]
  4. Science and technology project of Jiangxi Administration of traditional Chinese Medicine [2021Z011, 2020Z003]
  5. Jiangxi University of Chinese Medicine Graduate Innovation Fund [JZYC21S32, S202110412001]
  6. Establishment project of Jiangxi science and technology innovation platform [20212BCD42009]

向作者/读者索取更多资源

This study found that Schisandra chinensis and wine processed Schisandra chinensis can alleviate cardiovascular dysfunction, promote sleep, and improve abnormal cardiovascular system of rats by regulating neurotransmitters and amino acid levels.
Clinical studies have shown that insomnia and anxiety are usually accompanied by cardiovascular dysfunction. In traditional Chinese medicine, Schisandra chinensis (SC) and wine processed Schisandra chinensis (WSC) are mainly used for the treatment of dysphoria, palpitation and insomnia. However, little attention was paid to its mechanism. In this study, we monitored the effect of SC and WSC on the nervous system and cardiovascular system of free-moving rats in the real-time. Our results show that SC and WSC can alleviate cardiovascular dysfunction while promoting sleep, and we further explored their potential mechanisms. HPLC-QTOF-MS was used for the quality control of chemical components in SC and WSC. Data sciences international (DSI) physiological telemetry system was applied to collect the electroencephalogram (EEG), electrocardiogram (ECG) and other parameters of free-moving rats to understand the effects of long-term intake of SC and WSC on rats. The content of Cortisol (CORT), neurotransmitters and amino acids in rat pituitary and hypothalamus were analyzed by UPLC-MS to determine the activity of HPA axis. The expression of melatonin receptor MT1 was analyzed by immunofluorescence technique. Our results suggested that SC and WSC may play the role of promoting sleep by increasing the expression level of melatonin receptor MT1 in hypothalamus, and modulate the activity of HPA axis by regulating the levels of the related neurotransmitters and amino acid, so as to improve the abnormal cardiovascular system of rats. This study may provide theoretical support for explicating the advantages of SC and other phytomedicines in the treatment of insomnia.

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