期刊
PLACENTA
卷 114, 期 -, 页码 39-41出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2021.08.053
关键词
Placenta; Human; Giant cell; Extravillous trophoblast; Anchoring column; Decidua; Macrophage
Placental multinuclear giant cells are derived from trophoblastic elements, connected to extravillous cytotrophoblast cells, and formed as a terminal differentiation step during invasion stages, reducing the invasive population.
In view of controversy about the source of placental multinuclear giant cells, we have re-examined the literature which clearly shows they are derived from trophoblastic elements that have populated the decidua. Archival material for electron microscopy from 17 to 18 week placentae demonstrates they can be found connected via desmosomes to the outer extravillous cytotrophoblast cells of anchoring columns, thus identifying a primary source. We suggest their formation is a terminal differentiation step occurring at all stages of invasion from the cell column to the myometrium, progressively reducing the invasive population.
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