期刊
PLACENTA
卷 115, 期 -, 页码 53-59出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.placenta.2021.09.014
关键词
Autophagy; Pregnancy; Intrahepatic cholestasis of pregnancy
资金
- Science and Technology Department of Sichuan Province [2020YJ0082]
- Technological research and developmental innovation project of Chengdu
- Science and technology cooperation project of Sichuan University [2020CDZG23]
ICP, the most common liver disease during pregnancy, poses potential risks to fetal outcomes. Recent studies have highlighted the importance of autophagy in pregnancy and complications, suggesting its pivotal roles in pregnancy development and potential for improving care for pregnant women.
Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disease during pregnancy. Manifested with pruritus and elevation in bile acids, the etiology of ICP is still poorly understood. Although ICP is considered relatively benign for the mother, increased rates of adverse fetal outcomes including sudden fetal demise are possible devastating outcomes associated with ICP. Limited understanding of the underlying mechanisms restricted treatment options and managements of ICP. In recent decades, evolving evidence indicated the significance of autophagy in pregnancy and pregnancy complications. Autophagy is an ancient self-defense mechanism which is essential for cell survival, differentiation and development. Autophagy has pivotal roles in embryogenesis, implantation, and maintenance of pregnancy, and is involved in the orchestration of diverse physiological and pathological cellular responses in patients with pregnancy complications. Recent advances in these research fields provide tantalizing targets on autophagy to improve the care of pregnant women. This review summarizes recent advances in understanding autophagy in ICP and its possible roles in the causation and prevention of ICP.
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