Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

Article Oncology

Andrographolide Inhibits Proliferation of Colon Cancer SW-480 Cells via Downregulating Notch Signaling Pathway

Imran Khan et al.

Summary: The study demonstrated that andrographolide inhibits the growth of SW-480 cells by suppressing the Notch signaling pathway, inducing apoptosis, and inhibiting migratory and colony forming potential.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY (2021)

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Article Immunology

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

Sahabuddin Ahmed et al.

Summary: The communication between microglia activation and dopaminergic neuronal loss plays an important role in the progression of Parkinson's disease. Studying the NLRP3 inflammasome activation and its relation to mitochondrial dysfunction in microglia could provide insights into potential strategies to control neurodegeneration. Mitophagy regulation through Andrographolide treatment may help inhibit NLRP3 activation and rescue dopaminergic neuron loss.

BRAIN BEHAVIOR AND IMMUNITY (2021)

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Article Biochemical Research Methods

Andrographolide Mitigates Unfolded Protein Response Pathway and Apoptosis Involved in Chikungunya Virus Infection

Swati Gupta et al.

Summary: The study suggests that andrographolide is a potential remedy for chikungunya virus infection, as it can suppress virus-induced ER stress and apoptosis.

COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING (2021)

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Article Oncology

Andrographolide Induces Apoptosis and Cell Cycle Arrest through Inhibition of Aberrant Hedgehog Signaling Pathway in Colon Cancer Cells

Imran Khan et al.

Summary: Andrographolide can repress colon cancer cell growth by inhibiting the Hedgehog signaling pathway, inducing apoptosis, and inhibiting cell migration.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2021)

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Article Substance Abuse

Andrographis paniculata and Its Main Bioactive Ingredient Andrographolide Decrease Alcohol Drinking and Seeking in Rats Through Activation of Nuclear PPARγ Pathway

Serena Stopponi et al.

Summary: Extracts from Andrographis paniculata have been shown to reduce alcohol consumption in msP rats by activating PPAR gamma, and also prevent relapse of alcohol seeking behavior. This suggests that PPAR gamma activation mediated by A. paniculata could be a potential therapeutic strategy for treating alcohol use disorder.

ALCOHOL AND ALCOHOLISM (2021)

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Review Pharmacology & Pharmacy

What dominates the changeable pharmacokinetics of natural sesquiterpene lactones and diterpene lactones: a review focusing on absorption and metabolism

Ziwei Yu et al.

Summary: This review examines the pharmacokinetic characteristics of sesquiterpene lactones (STLs) and diterpene lactones (DTLs), showing that differences in treatment regimens and subjects can alter their absorption and metabolism, with emphasis on the impact of intestinal permeability, gastrointestinal pH, and efflux transporters. The metabolic behavior of the lactone ring, particularly the alpha, beta-unsaturated lactone moiety, plays a significant role in their metabolism, with phase I and II biotransformation involving enzymes like CYP450s and UGTs.

DRUG METABOLISM REVIEWS (2021)

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Article Biology

Influence of common dietary supplements (curcumin, andrographolide, and d-limonene) on the radiobiological responses of p53-competent colonic cancer epithelial cells

Dusan Vukmirovic et al.

Summary: The study aimed to investigate the radiomodulatory effects of curcumin, andrographolide, and d-limonene on human colonic epithelial cells, but found that they did not show significant radioprotective or radiomitigative properties. D-limonene was found to induce radiosensitization in post-irradiation administration. However, all three compounds did not modulate radiation-induced bystander signal production and response in the cells.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2021)

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Review Biochemical Research Methods

Andrographolide: A Review of Analytical Methods

Rashmi Patil et al.

Summary: Andrographolide, a bicyclic diterpenoid lactone, is considered a natural antibiotic with various bioactivities such as anti-inflammatory, antibacterial, antineoplastic, cardioprotective, hepatoprotective, and hypoglycaemic properties. This article reviews analytical methods for andrographolide in biological samples, pharmaceutical formulations, and plant materials, including spectrophotometry, chemiluminescence method, electroanalytical method, chromatography, and hyphenated techniques.

JOURNAL OF CHROMATOGRAPHIC SCIENCE (2021)

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Article Biochemistry & Molecular Biology

Andrographolide restores glucose uptake in rat hippocampal neurons

Camila Gherardelli et al.

Summary: Cerebral glucose hypometabolism is a common feature in many neurodegenerative diseases, and it has been shown that metabolic disturbances precede clinical symptoms. Andrographolide can enhance neuronal glucose uptake and metabolism, dependent on the activity of AMP-activated protein kinase.

JOURNAL OF NEUROCHEMISTRY (2021)

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Review Biochemistry & Molecular Biology

Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism

Rafael Agustin Burgos et al.

Summary: Andrographolide, the main active ingredient isolated from Andrographis paniculata, possesses diverse biological effects including anti-inflammatory, antioxidant, and antineoplastic properties. Its targets include transcription factors NF-kappa B, AP-1, and HIF-1, as well as signaling pathways such as PI3K/Akt, MAPK, and JAK/STAT. The increase in Nrf2 signaling pathway supports its antioxidant and anti-inflammatory properties, while recent evidence suggests that andrographolide may modulate glucose metabolism, potentially explaining its diverse therapeutic effects.

MOLECULES (2021)

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Article Veterinary Sciences

Andrographolide attenuates inflammatory response induced by LPS via activating Nrf2 signaling pathway in bovine endometrial epithelial cells

Kaiqiang Fu et al.

Summary: Andrographolide exhibits significant anti-inflammatory effects in the LPS-induced inflammatory response of bEECs by reducing the production of inflammatory factors through the activation of Nrf2.

RESEARCH IN VETERINARY SCIENCE (2021)

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Article Pharmacology & Pharmacy

Andrographolide inhibits IL-1β release in bone marrow-derived macrophages and monocyte infiltration in mouse knee joints induced by monosodium urate

Chia-Wen Lo et al.

Summary: The study aimed to investigate the effects of Andrographolide (AND) on gout-induced joint inflammation. The results demonstrated that AND attenuated MSU-induced joint inflammation by inducing HO-1 expression and inhibiting ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1 beta release.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2021)

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Article Genetics & Heredity

Genomic Characterization of WRKY Transcription Factors Related to Andrographolide Biosynthesis in Andrographis paniculata

Rongrong Zhang et al.

Summary: This study systematically identified WRKY transcription factors related to andrographolide biosynthesis and found that 7 WRKY genes may regulate the biosynthesis of andrographolide. This research lays a foundation for understanding the regulatory mechanism of andrographolide biosynthesis.

FRONTIERS IN GENETICS (2021)

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Article Biotechnology & Applied Microbiology

Encapsulation of Andrographolide in poly(lactide-co-glycolide) Nanoparticles: Formulation Optimization and in vitro Efficacy Studies

Bukola A. Oseni et al.

Summary: Andrographolide, a potential chemopreventive and chemotherapeutic agent, was encapsulated in PLGA nanoparticles using emulsion solvent evaporation technique to improve its therapeutic efficacy. The optimal formulation, with a polymer ratio of 85:15 lactide to glycolide and ethyl acetate as the organic solvent, demonstrated sustained release of the drug and significantly enhanced in vitro anticancer efficacy compared to free drug in a metastatic breast cancer cell line. Further in-depth efficacy studies are warranted for the nanoparticle formulation of andrographolide.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2021)

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Article Fisheries

Effects of andrographolide on lipopolysaccharide-induced serum biochemical indices, immune responses and intestinal inflammation related to gene expression of Monopterus albus

Yong Shi et al.

Summary: The study revealed that andrographolide can accelerate the recovery of serum indices and intestinal gene expression levels in Monopterus albus after LPS injection, effectively alleviating immune stress and inflammatory response.

AQUACULTURE RESEARCH (2021)

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Article Pharmacology & Pharmacy

Synergistic potential of dual andrographolide and melatonin targeting of metastatic colon cancer cells: Using the Chou-Talalay combination index method

Vivekjyoti Banerjee et al.

Summary: This research evaluated the synergistic effects of andrographolide (AGP) and melatonin (MLT) on metastatic colon cancer cells (mCRC) and colospheroids, demonstrating a synergistic relationship based on quantitative assessment of cell viability. The combination of AGP and MLT showed promising results in inhibiting cancer cell growth, providing rationale for further exploration of this combination therapy for colorectal cancer.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Review Plant Sciences

Anticancer potential of andrographolide from Andrographis paniculata (Burm.f.) Nees and its mechanisms of action

Zoya Malik et al.

Summary: This review emphasizes the medicinal importance of Andrographis paniculata and its phytoconstituent andrographolide, particularly focusing on its anticancer activity, mechanisms of action, biopharmaceutical properties, and development as an adjuvant therapy for cancer treatment. Various anticancer mechanisms of andrographolide have been identified, as well as efforts to improve its bioavailability through novel formulations.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Review Plant Sciences

Andrographis paniculata (Burm.f.) Nees and its major constituent andrographolide as potential antiviral agents

Maoyuan Jiang et al.

Summary: Andrographis paniculata is widely used in subtropical regions for treating various ailments and has potential antiviral properties.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Anti-SARS-CoV-2 Activity of Andrographis paniculata Extract and Its Major Component Andrographolide in Human Lung Epithelial Cells and Cytotoxicity Evaluation in Major Organ Cell Representatives

Khanit Sa-ngiamsuntorn et al.

Summary: This study investigated the anti-SARS-CoV-2 activity of Andrographis paniculata extract and andrographolide in human lung epithelial cells, showing that they significantly inhibited the production of infectious virions with low cytotoxicity. These findings suggest that A. paniculata and andrographolide have potential as monotherapy or in combination with other drugs against SARS-CoV-2 infection.

JOURNAL OF NATURAL PRODUCTS (2021)

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Article Biochemistry & Molecular Biology

The Effects of Andrographolide on the Enhancement of Chondrogenesis and Osteogenesis in Human Suprapatellar Fat Pad Derived Mesenchymal Stem Cells

Thitianan Kulsirirat et al.

Summary: Andrographolide can enhance osteogenesis and chondrogenesis of human mesenchymal stem cells from the suprapatellar fat pad, while suppressing adipogenic differentiation.

MOLECULES (2021)

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Article Cell Biology

Inhibition of Inducible Nitric Oxide Synthase (iNOS) by Andrographolide and In Vitro Evaluation of Its Antiproliferative and Proapoptotic Effects on Cervical Cancer

Akbar Pasha et al.

Summary: This study aimed to investigate the expression of inducible nitric oxide synthase (iNOS) in cervical cancer and identified a potential iNOS inhibitor. The research found that elevated iNOS levels were associated with poor survival and increased tumor aggressiveness in cervical cancer, and andrographolide may exert anti-cancer effects by inhibiting iNOS expression.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Review Chemistry, Medicinal

Andrographis paniculata (Burm. F) Wall ex Nees: Antiviral properties

Ashwini Khanderao Jadhav et al.

Summary: Andrographis paniculata is rich in molecules, particularly andrographolide and its derivatives, which exhibit diverse clinical properties such as antiviral, anticancer, and anti-inflammatory activities. However, the low bioavailability of andrographolide calls for the development of appropriate delivery systems to enhance its therapeutic potential. Further high-quality studies are necessary to establish the clinical efficacy of this plant.

PHYTOTHERAPY RESEARCH (2021)

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Article Cell & Tissue Engineering

Andrographolide promotes proliferative and osteogenic potentials of human placenta-derived mesenchymal stem cells through the activation of Wnt/β-catenin signaling

Naruphong Phunikom et al.

Summary: Andrographolide (AP) has been shown to promote proliferation, osteogenic differentiation, and bone formation of placenta-derived mesenchymal stem cells. It may be an effective novel agent for improving placenta-derived MSCs and stem cell-based therapy for bone regeneration. The compound enhances Wnt/beta-catenin signaling and osteoblast-specific gene expressions, promoting bone formation and increasing osteocalcin levels.

STEM CELL RESEARCH & THERAPY (2021)

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Article Pharmacology & Pharmacy

Andrographolide Against Lung Cancer-New Pharmacological Insights Based on High-Throughput Metabolomics Analysis Combined with Network Pharmacology

Wen Luo et al.

Summary: The study found that Andro exhibited significant protective effects against lung cancer, and metabolomics combined with network pharmacology analysis provided insight into its therapeutic mechanisms.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Positive Effect of Andrographolide Induced Autophagy on Random-Pattern Skin Flaps Survival

Jingtao Jiang et al.

Summary: Random-pattern skin flap replantation is commonly used for tissue reconstruction, and Andro has been shown to enhance flap viability by promoting angiogenesis, inhibiting apoptosis, and reducing oxidative stress. Additionally, Andro increases autophagy levels, which contribute to improved flap survival, and this effect can be reversed by the autophagy inhibitor 3-methyladenine.

FRONTIERS IN PHARMACOLOGY (2021)

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Article Multidisciplinary Sciences

A molecular dynamics simulation study of the ACE2 receptor with screened natural inhibitors to identify novel drug candidate against COVID-19

Neha Srivastava et al.

Summary: This study identified potential drugs against SARS-CoV-2, including cinnamic acid, thymoquinone, and andrographolide, which showed strong binding affinity to the ACE2 receptor. The molecular docking and MD simulation study helped understand the interactions between these compounds and the receptor binding site, providing insights for novel therapeutic interventions.

PEERJ (2021)

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Article Biochemistry & Molecular Biology

Andrographolide upregulates protein quality control mechanisms in cell and mouse through upregulation of mTORC1 function

Naibedya Dutta et al.

Summary: Andrographolide activates HSF1 and NRF2 pathways to ameliorate protein aggregation induced cellular toxicity in PD models. It achieves these functions through mTORC1 activation via p38 MAPK and ERK pathways, and NRF2 activation via mTORC1-mediated phosphorylation of p62/sequestosome 1. The induction of ROS levels by andrographolide underlies these activities in different cell types.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2021)

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Article Pharmacology & Pharmacy

The in vitro and in vivo study of novel formulation of andrographolide PLGA nanoparticle embedded into gelatin-based hydrogel to prolong delivery and extend residence time in joint

Thitianan Kulsirirat et al.

Summary: This study successfully prolonged the retention time of Andrographolide in the joint using PLGA nanocarriers and gelatin-based hydrogel, achieving sustained release for over 1 month. This provided a novel strategy for the local management of osteoarthritis disease.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

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Review Plant Sciences

Andrographis paniculata (Burm.f.) Nees: Traditional uses, phytochemistry, pharmacological properties and quality control/quality assurance

Sunil Kumar et al.

Summary: Andrographis paniculata is a medicinal herb used in Asian countries for various diseases. This review provides information on its traditional uses, phytochemistry, pharmacological properties, and chemical markers for quality control.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Pharmacology & Pharmacy

Optimization of Production Parameters for Andrographolide-Loaded Nanoemulsion Preparation by Microfluidization and Evaluations of Its Bioactivities in Skin Cancer Cells and UVB Radiation-Exposed Skin

Rathapon Asasutjarit et al.

Summary: The active compound Andrographolide was isolated from Andrographis paniculata, but its low water solubility posed challenges for product development. An AG-loaded nanoemulsion was prepared to address this issue. The study found that the optimized AG-NE had cytotoxic effects on skin cancer cells and improved skin disorders caused by UVB radiation.

PHARMACEUTICS (2021)

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Review Biochemistry & Molecular Biology

Polypharmacology of andrographolide: beyond one molecule one target

Quy T. N. Tran et al.

Summary: Andrographolide, a widely studied plant secondary metabolite, has diverse pharmacological targets associated with prevalent diseases. Despite documented efficacy in disease models, challenges such as multi-targeting properties and discrepancies in bioavailability have hindered its development as a therapeutic agent.

NATURAL PRODUCT REPORTS (2021)

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Article Pharmacology & Pharmacy

Comparing the pharmacokinetics of 13α,21-dihydroeurycomanone and eurycomanone exclusively enriched in Eurycoma longifolia extracts and their spermatogenesis enhancement in andrographolide-induced oligospermia in rats

Wan-Jie Chung et al.

Summary: This study focused on the pharmacokinetics of DHY, an understudied constituent of Eurycoma longifolia, and compared its spermatogenesis enhancement property with the predominant EN. Despite DHY showing better oral bioavailability, EN exhibited higher efficacy in spermatogenesis enhancement, indicating that EN remains the main chemical contributor to plant bioactivity. DHY-F and EN-F could potentially improve Eurycoma longifolia as a phytomedicine for male infertility, particularly oligospermia.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

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Article Plant Sciences

Andrographolide emeliorates maltol aluminium-induced neurotoxicity via regulating p62-mediated Keap1-Nrf2 pathways in PC12 cells

Jiaqi Lu et al.

Summary: The study revealed that Andro has potential therapeutic effects against aluminum-induced neurotoxicity by regulating the p62-mediated Keap1-Nrf2 pathways, significantly impacting cell viability and the expression levels of related proteins.

PHARMACEUTICAL BIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Combination of system biology to probe the anti-viral activity of andrographolide and its derivative against COVID-19

Pukar Khanal et al.

Summary: The study reveals a strong interaction between andrographolide and its derivative 14-deoxy-11,12-didehydroandrographolide with COVID-19 associated target proteins, showing different immunoregulatory pathways.

RSC ADVANCES (2021)

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Article Polymer Science

Andrographolide solid dispersions formulated by Soluplus to enhance interface wetting, dissolution, and absorption

Bing Song et al.

JOURNAL OF APPLIED POLYMER SCIENCE (2020)

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Article Plant Sciences

Andrographolide inhibits secretagogue-induced pseudo-allergic reaction

Zhi-Fang Lu et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2020)

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Article Neurosciences

Andrographolide Reduces Neuroinflammation and Oxidative Stress in Aged Octodon degus

Carolina B. Lindsay et al.

MOLECULAR NEUROBIOLOGY (2020)

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Review Pharmacology & Pharmacy

Effect of Andrographolide and Its Analogs on Bacterial Infection: A Review

Lulu Zhang et al.

PHARMACOLOGY (2020)

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Article Toxicology

Andrographolide ameliorates bleomycin-induced pulmonary fibrosis by suppressing cell proliferation and myofibroblast differentiation of fibroblasts via the TGF-β1-mediated Smad-dependent and-independent pathways

Jingpei Li et al.

TOXICOLOGY LETTERS (2020)

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Article Endocrinology & Metabolism

Antiproliferative and Apoptotic Properties Human Colon Cancer DLD1 Cell Line of Andrographolide Against

Imran Khan et al.

ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS (2020)

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Article Cell Biology

Neuroprotective effects of andrographolide on chronic cerebral hypoperfusion-induced hippocampal neuronal damage in rats possibly via PTEN/AKT signaling pathway

Da-Peng Wang et al.

ACTA HISTOCHEMICA (2020)

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Article Biochemistry & Molecular Biology

Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis

Shasha Luo et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2020)

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Article Environmental Sciences

Andrographolide mitigates cardiac apoptosis to provide cardio-protection in high-fat-diet-induced obese mice

Kuan-Ho Lin et al.

ENVIRONMENTAL TOXICOLOGY (2020)

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Article Pharmacology & Pharmacy

Oral andrographolide nanocrystals protect liver from paracetamol induced injury in mice

Aalok Basu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2020)

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Article Chemistry, Medicinal

Protective Effect of Andrographolide on Alleviating Chronic Alcoholic Liver Disease in Mice by Inhibiting Nuclear Factor Kappa B and Tumor Necrosis Factor Alpha Activation

Yuan Song et al.

JOURNAL OF MEDICINAL FOOD (2020)

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Article Biochemistry & Molecular Biology

Improvement of Oxazolone-Induced Ulcerative Colitis in Rats Using Andrographolide

Liuhong Zhang et al.

MOLECULES (2020)

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Article Oncology

Effects of Andrographolide on Intracellular pH Regulation, Cellular Migration, and Apoptosis in Human Cervical Cancer Cells (Running Tittle: Effects of Andrographolide on pH Regulators and Apoptosis in Cervical Cancer)

Shih-Hurng Loh et al.

CANCERS (2020)

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Article Pharmacology & Pharmacy

Andrographolide promotes pancreatic duct cells differentiation into insulin-producing cells by targeting PDX-1

Shengmei Zhang et al.

BIOCHEMICAL PHARMACOLOGY (2020)

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Article Clinical Neurology

Efficacy of andrographolide in not active progressive multiple sclerosis: a prospective exploratory double-blind, parallel-group, randomized, placebo-controlled trial

Ethel Ciampi et al.

BMC NEUROLOGY (2020)

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Article Immunology

Andrographolide attenuates oxidative stress injury in cigarette smoke extract exposed macrophages through inhibiting SIRT1/ERK signaling

Xin-fang Zhang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Oral Bioavailability Enhancement and Anti-Fatigue Assessment of the Andrographolide Loaded Solid Dispersion

Ching-Chi Yen et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Biotechnology & Applied Microbiology

Andrographolide mitigates cartilage damage via miR-27-3p-modulated matrix metalloproteinase13 repression

Shaojian Chen et al.

JOURNAL OF GENE MEDICINE (2020)

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Article Chemistry, Multidisciplinary

Gold Nanoparticles (AuNPs) Conjugated with Andrographolide Ameliorated Viper (Daboia russellii russellii) Venom-Induced Toxicities in Animal Model

Souray Ghosh et al.

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY (2020)

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Article Environmental Sciences

Determination of andrographolide sodium bisulfite in renal microdialysis fluid of rats and toxicokinetic study

Dongming Chen et al.

TOXICOLOGICAL AND ENVIRONMENTAL CHEMISTRY (2020)

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Article Immunology

Andrographolide sulfonate ameliorates chronic colitis induced by TNBS in mice via decreasing inflammation and fibrosis

Jianhua Gao et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Chemistry, Analytical

Pharmacokinetics of Andrographolide Sodium Bisulphite and its Related Substance in Rats by Liquid Chromatography-Tandem Mass Spectrometry

Shuang-Qing Zhang et al.

JOURNAL OF ANALYTICAL CHEMISTRY (2020)

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Review Oncology

The Prowess of Andrographolide as a Natural Weapon in the War against Cancer

Ammad Ahmad Farooqi et al.

CANCERS (2020)

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Article Cell Biology

Andrographolide attenuates epithelial-mesenchymal transition induced by TGF-β1 in alveolar epithelial cells

Jingpei Li et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Fisheries

Protective effects of andrographolide on lead-induced kidney injury through inhibiting inflammatory and oxidative responses in common carp

Yue Zhang et al.

Aquaculture Reports (2020)

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Article Health Care Sciences & Services

Andrographolide protects against endothelial dysfunction and inflammatory response in rats with coronary heart disease by regulating PPAR and NF-κB signaling pathways

Jia Shu et al.

ANNALS OF PALLIATIVE MEDICINE (2020)

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Article Medicine, Research & Experimental

Andrographolide enhanced radiosensitivity by downregulating glycolysis via the inhibition of the PI3K-Akt-mTOR signaling pathway in HCT116 colorectal cancer cells

Xiaofei Li et al.

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH (2020)

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Article Medicine, Research & Experimental

Protective effect of Andrographolide on 5-Fu induced intestinal mucositis by regulating p38 MAPK signaling pathway

Dao-Chun Xiang et al.

LIFE SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Andrographolide and its fluorescent derivative inhibit the main proteases of 2019-nCoV and SARS-CoV through covalent linkage

Tzu-Hau Shi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Biochemistry & Molecular Biology

Andrographolide attenuates choroidal neovascularization by inhibiting the HIF-1α/VEGF signaling pathway

Kaixuan Cui et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Cell Biology

Andrographolide modulates HNF4α activity imparting on hepatic metabolism

Minyi Zhang et al.

MOLECULAR AND CELLULAR ENDOCRINOLOGY (2020)

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Article Cell Biology

Andrographolide Exerts Antihyperglycemic Effect through Strengthening Intestinal Barrier Function and Increasing Microbial Composition of Akkermansia muciniphila

Hongming Su et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Chemistry, Medicinal

From irreversible to reversible covalent inhibitors: Harnessing the andrographolide scaffold for anti-inflammatory action

Quy T. N. Tran et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)

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Article Plant Sciences

Andrographolide attenuates complete freund's adjuvant induced arthritis via suppression of inflammatory mediators and pro-inflammatory cytokines

Swati Gupta et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Article Cell Biology

Andrographolide exerts anti-inflammatory effects in Mycobacterium tuberculosis-infected macrophages by regulating the Notch1/Akt/NF-κB axis

Weigang He et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2020)

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Article Oncology

Biodistribution of andrographolide to assess the interior-exterior relationship between the lung and intestine usingmicroPET

Qi Zhang et al.

THORACIC CANCER (2020)

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Article Agriculture, Dairy & Animal Science

Effects of Dietary Andrographolide Levels on Growth Performance, Antioxidant Capacity, Intestinal Immune Function and Microbioma of Rice Field Eel (Monopterus Albus)

Yong Shi et al.

ANIMALS (2020)

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Article Oncology

Improved osteogenic activity and inhibited bacterial biofilm formation on andrographolide-loaded titania nanotubes

Eryou Feng et al.

ANNALS OF TRANSLATIONAL MEDICINE (2020)

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Article Pharmacology & Pharmacy

Andrographolide promotes skeletal muscle regeneration after acute injury through epigenetic modulation

Ziqiang Wu et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2020)

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Article Pharmacology & Pharmacy

Andrographolide sulfate inhibited NF-κB activation and alleviated pneumonia induced by poly I:C in mice

Jian Cui et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2020)

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Article Multidisciplinary Sciences

In silico and in vitro studies on the anti-cancer activity of andrographolide targeting survivin in human breast cancer stem cells

Septelia Inawati Wanandi et al.

PLOS ONE (2020)

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Article Nanoscience & Nanotechnology

Nanoencapsulation of Andrographolide Rich Extract for the Inhibition of Cervical and Neuroblastoma Cancer Cells

Parisa Sanati et al.

JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2020)

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Review Chemistry, Medicinal

Ursolic acid: A systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model

Qiang Sun et al.

FITOTERAPIA (2020)

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Article Medicine, Research & Experimental

Andrographolide modulates OPG/RANKL axis to promote osteoblastic differentiation in MC3T3-E1 cells and protects bone loss during estrogen deficiency in rats

Duangrat Tantikanlayaporn et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Biochemistry & Molecular Biology

Andrographolide and Its 14-Aryloxy Analogues Inhibit Zika and Dengue Virus Infection

Feng Li et al.

MOLECULES (2020)

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Article Agricultural Engineering

Induction of root endosymbiosis as a highly sustainable and efficient strategy for overproduction of the medicinally important diterpenoid lactone-andrographolide in Andrographis paniculata (Burm. F.) Wall. ex Nees

Deepthi Suseelan Nair et al.

INDUSTRIAL CROPS AND PRODUCTS (2020)

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Review Plant Sciences

Evodiamine: A review of its pharmacology, toxicity, pharmacokinetics and preparation researches

Qiang Sun et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Integrative & Complementary Medicine

Andrographolide as a potent and promising antiviral agent

Latif Reshi et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2020)

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Article Biochemistry & Molecular Biology

Andrographolide Protects Against Adverse Cardiac Remodeling After Myocardial Infarction through Enhancing Nrf2 Signaling Pathway

Saiyang Xie et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2020)

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Article Biochemistry & Molecular Biology

Nitric oxide donor andrographolide enhances humoral and cell-mediated immune responses

Bing Zhang et al.

CELLULAR AND MOLECULAR BIOLOGY (2020)

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Article Cell Biology

Andrographolide protects chondrocytes from oxidative stress injury by activation of the Keap1-Nrf2-Are signaling pathway

Bo Li et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Oncology

Andrographolide sensitizes Hep-2 human laryngeal cancer cells to carboplatin-induced apoptosis by increasing reactive oxygen species levels

Wenjing Mao et al.

ANTI-CANCER DRUGS (2019)

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Article Biochemistry & Molecular Biology

Andrographolide induce human embryonic stem cell apoptosis by oxidative stress response

Huarong Huang et al.

MOLECULAR & CELLULAR TOXICOLOGY (2019)

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Article Pharmacology & Pharmacy

Effect of Carrier Lipophilicity and Preparation Method on the Properties of Andrographolide-Solid Dispersion

Guowei Zhao et al.

PHARMACEUTICS (2019)

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Article Orthopedics

Andrographolide stimulates osteoblastogenesis and bone formation by inhibiting nuclear factor kappa-B signaling both in vivo and in vitro

Chang Yongyun et al.

JOURNAL OF ORTHOPAEDIC TRANSLATION (2019)

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Article Nanoscience & Nanotechnology

Therapeutic potential of andrographolide-loaded nanoparticles on a murine asthma model

Shreyasi Chakraborty et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Chemistry, Analytical

Application of Electric Cell-Substrate Impedance Sensing to Investigate the Cytotoxic Effects of Andrographolide on U-87 MG Glioblastoma Cell Migration and Apoptosis

Sheng-Po Chiu et al.

SENSORS (2019)

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Review Pharmacology & Pharmacy

Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents

Hon Liong Soo et al.

DRUG DISCOVERY TODAY (2019)

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Article Clinical Neurology

Andrographolide Exerts Significant Antidepressant-Like Effects Involving the Hippocampal BDNF System in Mice

Jing-Jing Zhang et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion

Da-Peng Wang et al.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Andrographolide antagonizes the cigarette smoke-induced epithelial-mesenchymal transition and pulmonary dysfunction through anti-inflammatory inhibiting HOTAIR

Haibo Xia et al.

TOXICOLOGY (2019)

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Article Neurosciences

Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer's Disease

Pedro Cisternas et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Pharmacology & Pharmacy

Andrographolide Inhibits Cholangiocarcinoma Cell Migration by Down-Regulation of Claudin-1 via the p-38 Signaling Pathway

Phorutai Pearngam et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Review Medicine, Research & Experimental

A review for the neuroprotective effects of andrographolide in the central nervous system

Jiashu Lu et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Article Pharmacology & Pharmacy

Andrographolide alleviates Parkinsonism in MPTP-PD mice via targeting mitochondrial fission mediated by dynamin-related protein 1

Ji Geng et al.

BRITISH JOURNAL OF PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Neuroprotection of Andrographolide Against Microglia-Mediated Inflammatory Injury and Oxidative Damage in PC12 Neurons

Yuanzhen Xu et al.

NEUROCHEMICAL RESEARCH (2019)

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Article Pharmacology & Pharmacy

Andrographolide triggers autophagy-mediated inflammation inhibition and attenuates chronic unpredictable mild stress (CUMS)-induced depressive-like behavior in mice

Ji Geng et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2019)

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Article Pharmacology & Pharmacy

Successful Brain Delivery of Andrographolide Loaded in Human Albumin Nanoparticles to TgCRND8 Mice, an Alzheimer's Disease Mouse Model

Anna Rita Bilia et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Andrographolide Ameliorates Rheumatoid Arthritis by Regulating the Apoptosis-NETosis Balance of Neutrophils

Xiaohong Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Cell Biology

Andrographolide Protects against HG-Induced Inflammation, Apoptosis, Migration, and Impairment of Angiogenesis via PI3K/AKT-eNOS Signalling in HUVECs

Ming-Xia Duan et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Medicine, Research & Experimental

A proteomic analysis of the anti-dengue virus activity of andrographolide

Atchara Paemanee et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

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Review Biochemistry & Molecular Biology

Andrographolide, A Natural Antioxidant: An Update

Eugenie Mussard et al.

ANTIOXIDANTS (2019)

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Article Pharmacology & Pharmacy

Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK

Nami Kim et al.

BIOCHEMICAL PHARMACOLOGY (2019)

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Article Plant Sciences

Andrographolide is neither a human organic anion transporter 1 (hOAT1) substrate nor inhibitor

Yoong Min Chong et al.

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2019)

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Article Cell Biology

Andrographolide prevents human nucleus pulposus cells against degeneration by inhibiting the NF-κB pathway

Jianwei Liu et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

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Article Pharmacology & Pharmacy

Role of polymers as crystal growth inhibitors in coprecipitation via solution-enhanced dispersion by supercritical fluids (SEDS) to improve andrographolide dissolution from standardized Andrographis paniculata extract

Sin Yee Lee et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2019)

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Article Integrative & Complementary Medicine

In Vitro Antiplasmodium and Chloroquine Resistance Reversal Effects of Andrographolide

Zaid O. Ibraheem et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2019)

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Review Engineering, Multidisciplinary

Andrographolide Loaded in Micro- and Nano-Formulations: Improved Bioavailability, Target-Tissue Distribution, and Efficacy of the King of Bitters

Marta Casamonti et al.

ENGINEERING (2019)

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Article Cell Biology

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Jian Gao et al.

CELL DEATH & DISEASE (2019)

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Article Food Science & Technology

Quantitative Determination of Andrographolide and Related Compounds in Andrographis paniculata Extracts and Biological Evaluation of Their Anti-Inflammatory Activity

Emmanuelle Villedieu-Percheron et al.

FOODS (2019)

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Article Biology

Andrographolide as a therapeutic agent against breast and ovarian cancers

Swarna Latha Beesetti et al.

OPEN LIFE SCIENCES (2019)

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Article Pharmacology & Pharmacy

Beneficial effects of andrographolide in a rat model of autoimmune myocarditis and its effects on PI3K/Akt pathway

Qi Zhang et al.

KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY (2019)

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Article Multidisciplinary Sciences

Andrographolide attenuates imbalance of gastric vascular homeostasis induced by ethanol through glycolysis pathway

Huan Yao et al.

SCIENTIFIC REPORTS (2019)

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Article Multidisciplinary Sciences

Andrographolide binds to ATP-binding pocket of VEGFR2 to impede VEGFA-mediated tumor-angiogenesis

Kirti Kajal et al.

SCIENTIFIC REPORTS (2019)

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Article Biochemistry & Molecular Biology

Andrographolide Enhances TRAIL-Induced Apoptosis via p53-Mediated Death Receptors Up-Regulation and Suppression of the NF-kappa B Pathway in Bladder Cancer Cells

Yuyou Deng et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2019)

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Article Integrative & Complementary Medicine

Andrographolide Inhibits Oxidized LDL-Induced Cholesterol Accumulation and Foam Cell Formation in Macrophages

Hung-Chih Lin et al.

AMERICAN JOURNAL OF CHINESE MEDICINE (2018)

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Article Andrology

Andrographolide sensitizes prostate cancer cells to TRAIL-induced apoptosis

Ruo-Jing Wei et al.

ASIAN JOURNAL OF ANDROLOGY (2018)

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Article Medicine, Research & Experimental

Evaluation of the effect of andrographolide and methotrexate combined therapy in complete Freund's adjuvant induced arthritis with reduced hepatotoxicity

Fenfen Li et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Medicine, Research & Experimental

Andrographolide sulfonate improves Alzheimer-associated phenotypes and mitochondrial dysfunction in APP/PS1 transgenic mice

Ji Geng et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

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Article Oncology

Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer

Muhammad Torequl Islam et al.

CANCER LETTERS (2018)

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Article Biophysics

Solid lipid nanoparticles for delivery of andrographolide across the blood-brain barrier: in vitro and in vivo evaluation

Giulia Graverini et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2018)

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Article Pharmacology & Pharmacy

In vitro inhibitory effects of major bioactive constituents of Andrographis paniculata, Curcuma longa and Silybum marianum on human liver microsomal morphine glucuronidation: A prediction of potential herb-drug interactions arising from andrographolide, curcumin and silybin inhibition in humans

Verawan Uchaipichat

DRUG METABOLISM AND PHARMACOKINETICS (2018)

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Article Cell Biology

Andrographolide Ameliorates Atherosclerosis by Suppressing Pro-Inflammation and ROS Generation-Mediated Foam Cell Formation

Teng Wu et al.

INFLAMMATION (2018)

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Article Immunology

Andrographolide suppresses TRIF-dependent signaling of toll-like receptors by targeting TBK1

Ah-Yeon Kim et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article Immunology

Andrographolide sulfonate reduces mortality in Enterovirus 71 infected mice by modulating immunity

Min Li et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article Immunology

Andrographolide ameliorates silica induced pulmonary fibrosis

Sachin Karkale et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2018)

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Article Nanoscience & Nanotechnology

Nanoemulsion as a strategy for improving the oral bioavailability and anti-inflammatory activity of andrographolide

Ching-Chi Yen et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Nanoscience & Nanotechnology

Novel nanocrystal-based solid dispersion with high drug loading, enhanced dissolution, and bioavailability of andrographolide

Yueqin Ma et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2018)

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Article Agriculture, Multidisciplinary

Andrographolide Antagonizes INF-α-Induced IL-8 via Inhibition of NADPH Oxidase/ROS/NF-κB and Src/MAPKs/AP-1 Axis in Human Colorectal Cancer HCT116 Cells

Miaomiao Yuan et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2018)

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Article Medicine, Research & Experimental

Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis

Xuejia Kang et al.

MOLECULAR PHARMACEUTICS (2018)

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Article Nanoscience & Nanotechnology

Aortic plaque-targeted andrographolide delivery with oxidation-sensitive micelle effectively treats atherosclerosis via simultaneous ROS capture and anti-inflammation

Teng Wu et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2018)

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Article Oncology

Andrographolide Exhibits Anticancer Potential Against Human Colon Cancer Cells by Inducing Cell Cycle Arrest and Programmed Cell Death via Augmentation of Intracellular Reactive Oxygen Species Level

Imran Khan et al.

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL (2018)

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Article Cell Biology

Andrographolide Ameliorates Diabetic Cardiomyopathy in Mice by Blockage of Oxidative Damage and NF-κB-Mediated Inflammation

Ershun Liang et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Cell Biology

Andrographolide Ameliorates Liver Fibrosis in Mice: Involvement of TLR4/NF-κB and TGF-β1/Smad2 Signaling Pathways

Liteng Lin et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2018)

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Article Plant Sciences

Influence of andrographolide on the pharmacokinetics of warfarin in rats

Xiaoli Zhang et al.

PHARMACEUTICAL BIOLOGY (2018)

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Article Plant Sciences

Andrographolide relieved pathological pain generated by spared nerve injury model in mice

Huang-Chi Wang et al.

PHARMACEUTICAL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Binding Studies of Andrographolide with Human Serum Albumin: Molecular Docking, Chromatographic and Spectroscopic Studies

Deepika Godugu et al.

PROTEIN AND PEPTIDE LETTERS (2018)

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Article Pharmacology & Pharmacy

Natural product andrographolide alleviated APAP-induced liver fibrosis by activating Nrf2 antioxidant pathway

Hongyu Yan et al.

TOXICOLOGY (2018)

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Article Public, Environmental & Occupational Health

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Swati Gupta et al.

ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE (2018)

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Article Pharmacology & Pharmacy

mPEG-PLA Micelle for Delivery of Effective Parts of Andrographis Paniculata

Hailu Yao et al.

CURRENT DRUG DELIVERY (2018)

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Article Pharmacology & Pharmacy

Andrographolide Inhibits Mechanical and Thermal Hyperalgesia in a Rat Model of HIV-Induced Neuropathic Pain

Zhihua Yi et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Article Biochemistry & Molecular Biology

Andrographolide Protects PC12 Cells Against beta-Amyloid-Induced Autophagy-Associated Cell Death Through Activation of the Nrf2-Mediated p62 Signaling Pathway

Lili Gu et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

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Article Neurosciences

Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction

Xiang Li et al.

NEUROPHARMACOLOGY (2018)

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Article Multidisciplinary Sciences

Andrographolide enhances the anti-metastatic effect of radiation in Ras-transformed cells via suppression of ERK-mediated MMP-2 activity

Chih-Chia Yu et al.

PLOS ONE (2018)

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Article Chemistry, Multidisciplinary

Andrographolide inhibits human serum albumin fibril formations through site-specific molecular interactions

Aalok Basu et al.

RSC ADVANCES (2018)

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Article Neurosciences

Andrographolide Alleviates Acute Brain Injury in a Rat Model of Traumatic Brain Injury: Possible Involvement of Inflammatory Signaling

Li Tao et al.

FRONTIERS IN NEUROSCIENCE (2018)

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Article Physiology

Andrographolide Sulfonate Attenuates Acute Lung Injury by Reducing Expression of Myeloperoxidase and Neutrophil-Derived Proteases in Mice

Fei Gao et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Pharmacology & Pharmacy

Stealth and Cationic Nanoliposomes as Drug Delivery Systems to Increase Andrographolide BBB Permeability

Vieri Piazzini et al.

PHARMACEUTICS (2018)

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Article Oncology

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

Yulin Peng et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Electrospun PLGA membrane incorporated with andrographolide-loaded mesoporous silica nanoparticles for sustained antibacterial wound dressing

Yuhang Jia et al.

NANOMEDICINE (2018)

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Article Microbiology

Andrographolide Prevents EV-D68 Replication by Inhibiting the Acidification of Virus-Containing Endocytic Vesicles

Dongyin Wang et al.

FRONTIERS IN MICROBIOLOGY (2018)

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Article Chemistry, Multidisciplinary

Charge density and electrostatic potential of hepatitis C anti-viral agent andrographolide: an experimental and theoretical study

Saravanan Manjula et al.

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS (2018)

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Article Chemistry, Multidisciplinary

Andrographolide-loaded silk fibroin nanoparticles

Xu Zhongyu et al.

RSC ADVANCES (2018)

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Article Pharmacology & Pharmacy

Polysaccharide Encrusted Multilayered Nano-Colloidal System of Andrographolide for Improved Hepatoprotection

Nidhi Mishra et al.

AAPS PHARMSCITECH (2017)

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Review Virology

Broad-spectrum antiviral properties of andrographolide

Swati Gupta et al.

ARCHIVES OF VIROLOGY (2017)

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Article Chemistry, Medicinal

Pharmacokinetic and Pharmacodynamic Interaction of Andrographolide and Standardized Extract of Andrographis paniculata (Nees) with Nabumetone in Wistar Rats

Aishwarya Balap et al.

PHYTOTHERAPY RESEARCH (2017)

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Article Oncology

Andrographolide impedes cancer stemness and enhances radio-sensitivity in oral carcinomas via miR-218 activation

Po-Yu Yang et al.

ONCOTARGET (2017)

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Article Pharmacology & Pharmacy

A novel nanosuspension of andrographolide: Preparation, characterization and passive liver target evaluation in rats

Ligang Guo et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2017)

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Article Pharmacology & Pharmacy

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Clizia Guccione et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

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Article Biotechnology & Applied Microbiology

Andrographolide: antibacterial activity against common bacteria of human health concern and possible mechanism of action

Malabika Banerjee et al.

FOLIA MICROBIOLOGICA (2017)

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Article Nanoscience & Nanotechnology

Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by D-α-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate

Hongzhi Qiao et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2017)

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Article Pharmacology & Pharmacy

Liposomal andrographolide dry powder inhalers for treatment of bacterial pneumonia via anti-inflammatory pathway

Miao Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Biochemistry & Molecular Biology

Andrographolide Induces Cell Cycle Arrest and Apoptosis of Chondrosarcoma by Targeting TCF-1/SOX9 Axis

Huan-Tian Zhang et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2017)

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Article Plant Sciences

An ex vivo evaluation of the efficacy of andrographolide in modulating differential expression of transcription factors and target genes in periodontal cells and its potential role in treating periodontal diseases

R. Ambili et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

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Article Plant Sciences

Herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide on pharmacokinetic and pharmacodynamic of naproxen in rats

Aishwarya Balap et al.

JOURNAL OF ETHNOPHARMACOLOGY (2017)

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Article Biochemistry & Molecular Biology

Clinical application analysis of andrographolide total ester sulfonate injection, a traditional Chinese medicine licensed in China

Ying Zhao et al.

JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL SCIENCES (2017)

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Article Immunology

Andrographolide - A promising therapeutic agent, negatively regulates glial cell derived neurodegeneration of prefrontal cortex, hippocampus and working memory impairment

Sudeshna Das et al.

JOURNAL OF NEUROIMMUNOLOGY (2017)

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Article Immunology

Andrographolide inhibits influenza A virus-induced inflammation in a murine model through NF-κB and JAK-STAT signaling pathway

Yi Ding et al.

MICROBES AND INFECTION (2017)

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Article Medicine, Research & Experimental

Inhalable Andrographolide-β-cyclodextrin Inclusion Complexes for Treatment of Staphylococcus aureus Pneumonia by Regulating Immune Responses

Tongtong Zhang et al.

MOLECULAR PHARMACEUTICS (2017)

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Article Biochemistry & Molecular Biology

Andrographolide Suppresses MV4-11 Cell Proliferation through the Inhibition of FLT3 Signaling, Fatty Acid Synthesis and Cellular Iron Uptake

Xiao Chen et al.

MOLECULES (2017)

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Article Developmental Biology

Andrographolide disrupts meiotic maturation by blocking cytoskeletal reorganisation and decreases the fertilisation potential of mouse oocytes

Hong-xing Liang et al.

REPRODUCTION FERTILITY AND DEVELOPMENT (2017)

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Article Oncology

Anti-tumor effect of cisplatin in human oral squamous cell carcinoma was enhanced by andrographolide via upregulation of phospho-p53 in vitro and in vivo

Songjie Chen et al.

TUMOR BIOLOGY (2017)

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Article Oncology

Andrographolide inhibits arrhythmias and is cardioprotective in rabbits

Mengliu Zeng et al.

ONCOTARGET (2017)

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Article Oncology

Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

Chen-wei Pan et al.

ONCOTARGET (2017)

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Article Chemistry, Multidisciplinary

Elucidating the binding interaction of andrographolide with the plasma proteins: biophysical and computational approach

Daniel Pushparaju Yeggoni et al.

RSC ADVANCES (2017)

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Review Pharmacology & Pharmacy

Andrographolide, a New Hope in the Prevention and Treatment of Metabolic Syndrome

Muhammad T. Islam

FRONTIERS IN PHARMACOLOGY (2017)

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Article Pharmacology & Pharmacy

A Natural Triterpenoid Saponin as Multifunctional Stabilizer for Drug Nanosuspension Powder

Yingchong Chen et al.

AAPS PHARMSCITECH (2017)

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Article Parasitology

Andrographolide induces oxidative stress-dependent cell death in unicellular protozoan parasite Trypanosoma brucei

Malabika Banerjee et al.

ACTA TROPICA (2017)

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Article Chemistry, Applied

Chitosan-hyaluronic acid composite sponge scaffold enriched with Andrographolide-loaded lipid nanoparticles for enhanced wound healing

Rania Abdel-Basset Sanad et al.

CARBOHYDRATE POLYMERS (2017)

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Article Biochemistry & Molecular Biology

Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA

Liang Shi et al.

CHEMICO-BIOLOGICAL INTERACTIONS (2017)

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Review Chemistry, Medicinal

Multi-targeting Andrographolide and its Natural Analogs as Potential Therapeutic Agents

V. Kishore et al.

CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)

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Article Pharmacology & Pharmacy

Activity of andrographolide against dengue virus

Patcharee Panraksa et al.

ANTIVIRAL RESEARCH (2017)

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Article Toxicology

Metabolic changes in the urine of andrographolide sodium bisulfite-treated rats

J. D. Xu et al.

HUMAN & EXPERIMENTAL TOXICOLOGY (2016)

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Article Environmental Sciences

Andrographolide-induced apoptosis in human renal tubular epithelial cells: Roles of endoplasmic reticulum stress and inflammatory response

Li-Li Gu et al.

ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016)

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Article Pharmacology & Pharmacy

Development of a long-acting intramuscularly injectable formulation with nanosuspension of andrographolide

Liandong Hu et al.

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY (2016)

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Article Plant Sciences

Pharmacokinetic and pharmacodynamic herb-drug interaction of Andrographis paniculata (Nees) extract and andrographolide with etoricoxib after oral administration in rats

Aishwarya Balap et al.

JOURNAL OF ETHNOPHARMACOLOGY (2016)

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Article Oncology

Pro-neurogenic effects of andrographolide on RSC96 Schwann cells in vitro

Fuben Xu et al.

MOLECULAR MEDICINE REPORTS (2016)

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Article Chemistry, Medicinal

Preparation and Evaluation of Andrographolide Solid Dispersion Vectored by Silicon Dioxide

Dingkun Zhang et al.

PHARMACOGNOSY MAGAZINE (2016)

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Review Chemistry, Medicinal

A Critical Approach to Evaluating Clinical Efficacy, Adverse Events and Drug Interactions of Herbal Remedies

Angelo A. Izzo et al.

PHYTOTHERAPY RESEARCH (2016)

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Article Oncology

Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation

Shuang Peng et al.

ONCOTARGET (2016)

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Article Integrative & Complementary Medicine

A new biocompatible microemulsion increases extraction yield and bioavailability of Andrographis paniculata

Liu Xiao-Yan et al.

CHINESE JOURNAL OF NATURAL MEDICINES (2016)

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Article Integrative & Complementary Medicine

Andrographolide Enhances Proliferation and Prevents Dedifferentiation of Rabbit Articular Chondrocytes: An In Vitro Study

Li-ke Luo et al.

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2015)

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Article Pharmacology & Pharmacy

Dry state microcrystals stabilized by an HPMC film to improve the bioavailability of andrographolide

Yu Zhang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2015)

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Article Oncology

Inhibition of MDA-MB-231 breast cancer cell migration and invasion activity by andrographolide via suppression of nuclear factor-κB-dependent matrix metalloproteinase-9 expression

Zanjing Zhai et al.

MOLECULAR MEDICINE REPORTS (2015)

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Article Biochemistry & Molecular Biology

被撤回的出版物: Andrographolide Suppress Tumor Growth by Inhibiting TLR4/NF-kappa B Signaling Activation in Insulinoma (Retracted article. See vol. 17, pg. 4092, 2021)

Qian-Qian Zhang et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2014)

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Article Pharmacology & Pharmacy

Development of andrographolide loaded PLGA microspheres: Optimization, characterization and in vitro-in vivo correlation

Yunxia Jiang et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2014)

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Article Chemistry, Applied

Preparation and characterisation of andrographolide niosomes and its anti-hepatocellular carcinoma activity

Y. S. Tu et al.

JOURNAL OF MICROENCAPSULATION (2014)

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Article Urology & Nephrology

Andrographolide induced acute kidney injury: Analysis of 26 cases reported in Chinese Literature

Wu-Xing Zhang et al.

NEPHROLOGY (2014)

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Article Plant Sciences

Pharmacokinetic analysis and tissue distribution of andrographolide in rat by a validated LC-MS/MS method

Rammohan Bera et al.

PHARMACEUTICAL BIOLOGY (2014)

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Article Pharmacology & Pharmacy

Bioavailability of andrographolide and protection against carbon tetrachloride-induced oxidative damage in rats

Haw-Wen Chen et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2014)

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Article Biochemical Research Methods

Comparative pharmacokinetic studies of andrographolide and its metabolite of 14-deoxy-12-hydroxy-andrographolide in rat by ultra-performance liquid chromatography-mass spectrometry

Tao Yang et al.

BIOMEDICAL CHROMATOGRAPHY (2013)

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Article Biochemical Research Methods

A novel flow-injection chemiluminescence method for determination of andrographolide in andrographis tablets

Zejun Jiang et al.

DRUG TESTING AND ANALYSIS (2013)

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Article Pharmacology & Pharmacy

Liquid and solid self-microemulsifying drug delivery systems for improving the oral bioavailability of andrographolide from a crude extract of Andrographis paniculata

Namfa Sermkaew et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2013)

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Article Biochemistry & Molecular Biology

Enhancement of absorption and hepatoprotective potential through soya-phosphatidylcholine-andrographolide vesicular system

Pushpendra Kumar Jain et al.

JOURNAL OF LIPOSOME RESEARCH (2013)

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Article Biochemical Research Methods

Comparative metabolism and stability of andrographolide in liver microsomes from humans, dogs and rats using ultra-performance liquid chromatography coupled with triple-quadrupole and Fourier transform ion cyclotron resonance mass spectrometry

Hai-Yu Zhao et al.

RAPID COMMUNICATIONS IN MASS SPECTROMETRY (2013)

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Article Biochemical Research Methods

Determination of andrograpolide sodium bisulphite in Beagle dog plasma by LC-MS/MS and its application to pharmacokinetics

Shuang-Qing Zhang et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2012)

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Article Chemistry, Applied

Preparation and evaluation of andrographolide-loaded microemulsion

Hong Du et al.

JOURNAL OF MICROENCAPSULATION (2012)

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Article Chemistry, Medicinal

Poor Oral Bioavailability of a Promising Anticancer Agent Andrographolide is Due to Extensive Metabolism and Efflux by P-Glycoprotein

Ling Ye et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

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Andrographolide: A review of its pharmacology, pharmacokinetics, toxicity and clinical trials and pharmaceutical researches

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