期刊
PHYTOTHERAPY RESEARCH
卷 36, 期 3, 页码 1326-1337出版社
WILEY
DOI: 10.1002/ptr.7391
关键词
curcumin; inflammation; neurological function; p38; MAPK
资金
- Gansu Province Health Industry Research Project [GSWSKY2018-01]
- Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital [CY2017-BJ15, CY2021-MS-B11]
- Cuiying Scientific and Special fund project for doctoral training program of Lanzhou University Second Hospital [YJS-BD-31]
- Natural Science Foundation of Gansu Province [21JR1RA128]
- National Natural Science Foundation of China [81771297]
This study demonstrates the protective effect of curcumin on traumatic brain injury (TBI) and its molecular mechanisms involving the p38/MAPK signaling pathway. Curcumin ameliorates secondary brain injury and inflammation associated with TBI, indicating its potential as a therapeutic approach for TBI-related inflammation.
Traumatic brain injury (TBI) is a common disease worldwide with a high mortality and disability rate and is closely related to the inflammatory response. However, the molecular mechanisms during the pathophysiological responses are not completely understood. This study was conducted to investigate the protective effect of curcumin on TBI and the molecular mechanisms of the p38/MAPK signal pathway. We found that curcumin remarkably ameliorated secondary brain injury after TBI, including effects on the neurological severity score and inflammation. After injection of curcumin, the neurological function score of mice decreased significantly. Curcumin exhibited antiinflammatory pharmacological effects, as reflected by inhibition of inflammatory factors (e.g., interleukin [IL]-1 beta, IL-6, and tumor necrosis factor [TNF]-alpha). Additionally, curcumin notably reduced the expression of p-p38 according to western blotting and immunohistochemical analyses. In conclusion, curcumin remarkably alleviated posttraumatic inflammation and thus shows potential for treating inflammation associated with TBI.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据