期刊
PHYTOMEDICINE
卷 91, 期 -, 页码 -出版社
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2021.153712
关键词
Cytokines; Inflammatory response; Interleukins; Interferon
资金
- Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology (Govt. of India), Trivandrum, Kerala, India
- Department of Science and Technology, Govt. of India, New Delhi [DST/TDT/DDP-04/2018(G)]
Inflammatory responses are complex immune mechanisms that recruit various immune cells and chemical mediators to initiate the healing process. Cytokines play a crucial role in inflammation, with abrupt expression and hyperinflammatory responses leading to various inflammatory disorders.
Inflammatory responses arise as an outcome of tissues or organs exposure towards harmful stimuli like injury, toxic chemicals or pathogenic microorganism. It is a complex cascade of immune mechanism to overcome from tissue injury and to initiate the healing process by recruiting various immune cells, chemical mediators such as the vasoactive peptides and amines, pro-inflammatory cytokines, eicosanoids and acute-phase proteins to prevent tissue damage and ultimately complete restoration of the tissue function. The cytokines exhibits a central function in communication between the cells, inflammatory response initiation, amplification and their regulation. This review covers the importance of inflammatory responses; the significance of cytokines in inflammation and numerous inflammatory disorders/ailments due to the abrupt expression of cytokines and the hyperinflammatory response or cytokine storm associated with poor prognosis in COVID-19 pandemic. Also highlighting the importance of naturally derived anti-inflammatory metabolites to overcome the side-effects of currently prevailing anti-inflammatory drugs.
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