(±)-Stagonosporopsin A, stagonosporopsin B and stagonosporopsin C, antibacterial metabolites produced by endophytic fungus Stagonosporopsis oculihominis

A successive investigation of the endophytic fungus Stagonosporopsis oculihominis isolated from Dendrobium huoshanense led to the discovery of two undescribed secondary metabolites, (+/-)-stagonosporopsin A and stagonosporopsin B, and a new natural product, stagonosporopsin C. (+/-)-stagonosporopsin A is a pair of enantiomer. The structures of the isolated compounds, including their absolute configurations, were elucidated based on extensive spectroscopic analyses, electronic circular dichroism (ECD) calculations and X-ray diffraction. Stagonosporopsin C exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with an MIC50 value of 41.3 mu M.

Automated summary

A successive investigation of the endophytic fungus Stagonosporopsis oculihominis isolated from Dendrobium huoshanense led to the discovery of two undescribed secondary metabolites, (+/-)-stagonosporopsin A and stagonosporopsin B, and a new natural product, stagonosporopsin C. Stagonosporopsin C exhibited moderate inhibitory activity against Staphylococcus aureus subsp. aureus ATCC29213 with an MIC50 value of 41.3 μM.