Euphorfinoids E-L: Diterpenoids from the roots of Euphorbia fischeriana with acetylcholinesterase inhibitory activity

Eight undescribed diterpenoids, euphorfinoids E-L, together with twelve known analogues, were isolated from the roots of wild Euphorbia fischeriana. Their structures and absolute configurations were elucidated by a combination of NMR, MS, ECD, and X-ray diffraction analyses. The plausible biosynthetic pathway of 1 was also proposed. The isolated compounds displayed moderate inhibitory activity against acetylcholinesterase (AChE) with 50% inhibiting concentration (IC50) values of 6.23-192.38 mu M.

Automated summary

This study isolated eight new diterpenoids from the roots of wild Euphorbia fischeriana, identified their structures and absolute configurations, and proposed a plausible biosynthetic pathway. These compounds showed moderate inhibitory activity against acetylcholinesterase, with IC50 values ranging from 6.23 to 192.38 µM.