期刊
PHYTOCHEMISTRY
卷 194, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2021.113020
关键词
Magnolia officinalis var; biloba; Magnoliaceae; Structural determination; Oligomeric neolignan; Cytotoxicity; Neuroprotection
资金
- National Natural Science Foundation of China [81730093, 2210070679]
- Independent project of State Key Laboratory of Bioactive Substance and Function of Natural Medicines [GTZA201803]
Six pairs of enantiomeric obovatol dimeric neolignans were isolated from the bark of Magnolia officinalis var. biloba, with one enantiomer showing cytotoxic activity against human cancer cell lines and two others exhibiting neuroprotective effects on glutamic acid-induced cellular damage.
(+)/(-)-Diobolignans A-F, six pairs of enantiomeric obovatol dimeric neolignans, were isolated from the bark of Magnolia officinalis var. biloba. (+)/(-)-Diobolignans A to C possessed a dioxane ring between the benzene ring and the propyl side chain, while (+)/(-)-diobolignans D to F possessed a furan ring. Meanwhile, (+)/(-)-diobolignans B and C, as well as (+)/(-)-diobolignans E and F, were two epimeric pairs of enantiomers, respectively. Their structures were determined by extensive analyses of HRESIMS, UV, IR, NMR and electronic circular dichroism (ECD) calculations. The bioassay showed (+)-diobolignan A displayed cytotoxic activities against human cancer cell lines HGC27 and HT29 with the IC50 values of 9.43 and 9.45 mu M, respectively. In addition, (-)-diobolignan A and (+/-)-diobolignan E showed neuroprotective effect on glutamic acid-induced cellular damage in SK-N-SH cell.
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